A study of the molecular properties of water in hydrated mannitol.

An understanding of the properties of water in hydrated saccharides and saccharide derivatives is relevant to a number of pharmaceutical processes, including wet granulation. This study uses a range of physical measurement techniques [viz. nuclear magnetic resonance spectroscopy (NMR), dielectric relaxation spectroscopy (DRS), near infrared spectroscopy (NIR), and differential scanning calorimetry (DSC)] to analyze the molecular properties of water in hydrated mannitol (containing up to 0.