The submillisecond acuity for detecting rapid spatial and temporal fluctuations in acoustic stimuli observed in humans and laboratory animals depends in part on select groups of auditory neurons that preserve synchrony from the ears to the binaural nuclei in the brainstem. These fibers have specialized synapses and axons that use a low-threshold voltage-activated outward current, I, conducted through Kv1 potassium ion channels. These are in turn coupled with HCN channels that express a mixed cation inward mixed current, I, to support precise synchronized firing.
View Article and Find Full Text PDFGenes Kcna1 and Kcna2 code for the voltage-dependent potassium channel subunits Kv1.1 and Kv1.2, which are coexpressed in large axons and commonly present within the same tetramers.
View Article and Find Full Text PDFMany central auditory nuclei preserve the tonotopic organization of their afferent inputs, generating a frequency "map" across the nucleus. In the medial nucleus of the trapezoid body (MNTB) the most medial neurons receive inputs corresponding to the highest frequency sounds and the most lateral neurons have the lowest characteristic frequencies. Whole-cell patch recording from MNTB principal neurons in rat brainstem slices demonstrates a corresponding tonotopic organization of voltage-gated outward potassium currents.
View Article and Find Full Text PDFA low voltage-activated potassium current, IKL, is found in auditory neuron types that have low excitability and precisely preserve the temporal pattern of activity present in their presynaptic inputs. The gene Kcna1 codes for Kv1.1 potassium channel subunits, which combine in expression systems to produce channel tetramers with properties similar to those of IKL, including sensitivity to dendrotoxin (DTX).
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