Publications by authors named "Helen K Brown"

This work reports on the synthesis of nine materials containing Cu, Ag, Au, and Ag/Cu nanoparticles (NPs) deposited on magnetite particles coated with polydopamine (PDA). Ag NPs were deposited on two PDA@Fe3O4 supports differing in the thickness of the PDA film. The film thickness was adjusted to impart a textural porosity to the material.

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Article Synopsis
  • Lesch-Nyhan disease (LND) results from mutations in the HPRT gene, which is vital for recycling purine nucleotides, leading to neurological issues.
  • Researchers created HPRT knock-out rats to explore the effects of this mutation on brain function, finding them viable and fertile but with notable metabolic changes in brain biochemistry.
  • Analysis showed decreased dopamine levels in these rats, reflecting similar deficits in humans with LND, suggesting this model could help further understand the disease's impact on neural function and behavior.
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Vaccinia virus (VACV) is a large double-stranded DNA virus with a complex cytoplasmic replication cycle that exploits numerous cellular proteins. This work characterises the role of a proviral cellular protein, the small GTPase RAB1A, in VACV replication. Using siRNA, we identified RAB1A as required for the production of extracellular enveloped virions (EEVs), but not intracellular mature virions (IMVs).

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The influence of weather on deep venous thrombosis (DVT) incidence remains controversial. We aimed to characterize the temporal association between DVT and meteorological variables including atmospheric pressure. Data relating to hospital admissions with DVT in Scotland were collected retrospectively for a 20 year period for which corresponding meteorological recordings were available.

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