EMD386088 (5 mg/kg) has no effect on latent inhibition shown to both light and noise stimuli.

Activation of 5-hydroxytyptamine (5-HT) receptors stimulates attentional switching and 5-HT receptor antagonists are putative drugs for psychosis. Latent inhibition (LI) provides a pre-clinical model of attentional switching and 'antipsychotic-like' action and is known to be modulated by 5-hydroxytyptamine. In the present study, LI was shown in a fear conditioning procedure that measured suppression of drinking after conditioning with footshock.