Temporal Relationship Between Depressive Symptoms and Cognition in Mid and Late Life: A Longitudinal Cohort Study.

Objectives: To examine the bidirectional temporal relationship between depressive symptoms and cognition in relation to risk, reaction, and prodrome.

Design: Cross-lag analysis of longitudinal data collected online at baseline and 12-month follow-up.

Setting And Participants: A United Kingdom population cohort of 11,855 participants aged 50 years and over.

Differences in memory function between 5-HT1A receptor genotypes in patients with major depressive disorder.

Background: While extensive literature on the role of the serotonin receptor 1A (5-HT1A-R) in cognition exists, the findings are largely from animal studies. There has been little research conducted into 5-HT1A-R genotypes and cognitive function in humans. This article evaluates the role of 5-HT1A-R genotypes on the profile of cognitive function in patients with major depressive disorder (MDD).