NQO1 C609T polymorphism associated with esophageal cancer and gastric cardiac carcinoma in North China.

Aim: To investigate the association of the NQO1 (C609T) polymorphism with susceptibility to esophageal squamous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) in North China.

Methods: The NQO1 C609T genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis in 317 cancer patients (193 ESCC and 124 GCA) and 165 unrelated healthy controls.

Results: The NQO1 C609T C/C, C/T and T/T genotype frequency among healthy controls was 31.