Publications by authors named "Helen F Titmarsh"
Article Synopsis
- The extracellular matrix (ECM) is important in cancer because it can help tumors grow and make treatments less effective.
- Scientists studied lung cancer tissue to find differences in the ECM between cancerous and normal tissues.
- They discovered 161 proteins related to the ECM that can help identify lung cancer and found some new markers that could predict how well patients might do after treatment.
Background: The major physiological role of vitamin D has traditionally been considered to be the regulation of calcium homeostasis and maintenance of skeletal health. However, there is increasing evidence that vitamin D influences a wider range of physiological processes including erythropoiesis. Vitamin D (25-hydroxyvitamin D, 25(OH)D) deficiency concentrations have been associated with anaemia in human beings.
View Article and Find Full Text PDFStudy of the c-Met-HGF axis in non-small cell lung cancer (NSCLC) has focused on the roles of c-MET signaling in neoplastic epithelial cells and the secretion of its ligand hepatocyte growth factor (HGF) by tumor stromal cells. However, there is increasing evidence that some leukocyte sub-sets also express c-MET raising the possibility of an immunomodulatory role for this axis. Consequently, the role of the c-MET- HGF axis in immunoncology is an active area of ongoing research.
View Article and Find Full Text PDFFeline immunodeficiency virus (FIV) is a lentivirus that can lead to a syndrome of acquired immune dysfunction. Infected cats often remain asymptomatic for several years before immune dysfunction leads to an increased risk for the development of systemic diseases, neoplasia and opportunistic infections. FIV is structurally related to human immunodeficiency virus (HIV) and the pathogenesis of FIV-related disease is similar to that seen in HIV-infected patients.
View Article and Find Full Text PDFObjectives Vitamin D deficiency, as assessed by serum 25-hydroxyvitamin D (25[OH]D) concentrations, has been linked to markers of systemic inflammation in human and canine medicine. However, the relationship between vitamin D status and inflammation has not been previously investigated in cats. The aim of this study was to examine the relationship between serum 25(OH)D concentrations and leukocyte counts in hospitalised sick cats.
View Article and Find Full Text PDFArticle Synopsis
- * The study hypothesized that lower vitamin D status in dogs with CE would correlate with higher levels of systemic and gastrointestinal inflammation, and analyzed various inflammatory markers alongside serum vitamin D levels.
- * Findings showed that lower vitamin D levels were associated with higher counts of neutrophils and monocytes, indicating a more inflammatory state in dogs, raising questions about whether low vitamin D is a cause or an effect of inflammation.