(±) cis-Bisamido epoxides: A novel series of potent FXIII-A inhibitors.

A novel class of potent FXIII-A inhibitors containing a (±) cis-bisamido epoxide pharmacophore is described. The compounds display highly potent inhibition of FXIII-A (IC50 = 5-500 nM) in an in vitro assay. In contrast to other types of previously described covalent transglutaminase inhibitors, the bis-amido epoxides exhibited no measurable reactivity with glutathione, therefore possibly rendering this class of compounds suitable for future in vivo investigations.

A nurse's role in promoting social capital in children and young people.

Enabling children's wellbeing by supporting their social networks is an important role of children's nurses. This article presents the concept of social capital as a cognitive tool to help nurses reflect on why and how supporting these networks is important. Through three case studies the authors introduce the attributes of social capital and how these may be applied and inform practice in hospital and community healthcare settings.

Percutaneous device closure of atrial septal defect results in very early and sustained changes of right and left heart function.

Objectives: To investigate the echocardiographic effects of percutaneous closure of secundum atrial septal defect (ASD) in adults and assess which pre-closure parameters predict good response to closure.

Background: ASD is a common congenital heart disease often undiscovered until adulthood. ASD closure has been revolutionized by the use of percutaneous devices.

Echocardiographic detection of atrial septal defects: the forgotten view.

The right parasternal view is conventionally used to assess the aortic valve and the ascending aorta. We describe two cases in which the right parasternal view was helpful in assessment of the interatrial septum and the detection of atrial septal defects (ASD), including one case in which this view confirmed the presence of a defect not seen in any other echocardiographic view. Use of the right parasternal view should be considered for assessment of the interatrial septum, particularly when there is a high index of suspicion for an atrial septal defect but no defect is seen on conventional views.

The impact of exposure to domestic violence on children and young people: a review of the literature.

Objective: This article reviews the literature concerning the impact of exposure to domestic violence on the health and developmental well-being of children and young people. Impact is explored across four separate yet inter-related domains (domestic violence exposure and child abuse; impact on parental capacity; impact on child and adolescent development; and exposure to additional adversities), with potential outcomes and key messages concerning best practice responses to children's needs highlighted.

Method: A comprehensive search of identified databases was conducted within an 11-year framework (1995-2006).