Steady-state pharmacokinetics of pravastatin in children with familial hypercholesterolaemia.

Objective: To determine pharmacokinetic data for pravastatin in children, since current data are insufficient in this age group.

Subjects And Methods: A 2-week, multiple-dose, steady-state pharmacokinetic study was carried out with pravastatin 20mg daily in 24 children with familial hypercholesterolaemia (aged 8-16 years; 12 prepubertal, 12 pubertal). A plasma concentration-time curve was performed on day 14.

Pharmacokinetics of mesalazine pellets in children with inflammatory bowel disease.

Mesalazine is a first-line drug in pediatric inflammatory bowel disease (IBD), and is customarily used to induce and maintain remission in mild to moderate disease. In children, pharmacokinetic data are scarce, and dosage recommendations are largely extrapolated from studies in adults. Aim of the study was to obtain the pharmacokinetic profile of a new mesalazine pellet formulation in children with ulcerative colitis and Crohn's colitis.