Publications by authors named "Hele Na Ce Rule"
Article Synopsis
- The aspartic protease plasmepsin X (PMX) is crucial for the malaria parasite's lifecycle, making it a target for new antimalarial treatments.
- Researchers developed a series of macrocyclic compounds based on initial screening hits, significantly enhancing the potency and stability of these PMX inhibitors.
- One lead compound demonstrated strong effectiveness in inhibiting parasite growth and cleared infected mice's blood stage when given orally, indicating its potential as a viable antimalarial drug.
