Allelic loss at 10q26 in osteosarcoma in the region of the BUB3 and FGFR2 genes.

Loss of heterozygosity at 10q26 was mapped using microsatellite markers in 20 osteosarcomas. A four-megabase region centered on marker D10S587 was affected by allelic loss in 60 percent of osteosarcomas. The most frequently lost marker was D10S1723.