Publications by authors named "Helder A R Pontes"
An expansile, mixed radiolucent-radiopaque lesion of the maxilla.
Oral Surg Oral Med Oral Pathol Oral Radiol
November 2024
Oral manifestations of peripheral T cell lymphoma, not otherwise specified: case series and review of the current literature.
Oral Surg Oral Med Oral Pathol Oral Radiol
August 2024
Article Synopsis
- - The study analyzed peripheral T-cell lymphoma, not otherwise specified (PTCL NOS) cases that impacted the oral cavity, reviewing both pathology files and existing literature about the condition.
- - Five cases were investigated, primarily affecting middle-aged males and females, with symptoms like destructive lesions in the palate, gingiva, and maxillary bone leading to severe health issues.
- - PTCL NOS in the oral cavity is rare, aggressive, and typically has a poor prognosis, with four out of five patients succumbing to the disease during follow-up.
This article aims to explore the integration of ChatGPT, an advanced conversational artificial intelligence model, in the field of dentistry. The review primarily consists of information related to the capabilities and functionalities of ChatGPT and how these abilities can aid dental professionals. This study includes data from research papers, case studies, and relevant literature on language models, as well as papers on dentistry, patient communication, dental education, and clinical decision-making.
View Article and Find Full Text PDFArticle Synopsis
- Pyodermatitis-pyostomatitis vegetans (PPV) is a rare disease indicated by pustules that often signals inflammatory bowel disease (IBD), with oral manifestations known as pyostomatitis vegetans (PSV).
- A study analyzed various cases of PSV from literature to identify key diagnostic features, including specific appearances of oral lesions and their relation to IBD.
- The research found 77 PSV cases with helpful diagnosis indicators but noted the lack of a standardized treatment approach, which typically involves multiple medications like corticosteroids and immunosuppressives, and highlighted a high risk of oral lesion recurrence upon dosage changes.
Article Synopsis
- - Follicular lymphoma is a type of cancer arising from B cells in the germinal center, often identified through microscopic and molecular analysis, particularly in the oral cavity.
- - A study evaluated 20 cases of oral follicular lymphoma, noting similar occurrences in men and women, with lesions commonly found in the palate and buccal mucosa, and a majority classified as grades 1 and 2.
- - Genetic testing revealed various translocations in specific genes, with the overall survival rate at 88% over two years, indicating that while these lymphomas are rare in the mouth, they typically present as non-ulcerated swellings.
Article Synopsis
- Amyloidosis can present with various systemic signs and challenging oral symptoms, prompting this study to examine its features specifically in the oral cavity.
- The study analyzed 26 biopsies from 23 patients, finding that 67% showed oral symptoms as the first sign of amyloidosis, with amyloid deposits located in several tissues surrounding nerves and muscles.
- Results suggest that oral biopsies are a valuable diagnostic tool for identifying amyloidosis, even in cases without visible oral symptoms, due to their ability to detect amyloid deposits effectively.
Contribution of public oral pathology services to the diagnosis of oral and oropharyngeal cancer in Brazil.
Braz Oral Res
December 2023
This study aimed to evaluate the contribution of oral and maxillofacial pathology laboratories (OMPLs) in Brazilian public universities to the diagnosis of lip, oral cavity, and oropharyngeal squamous cell carcinoma (SCC). A cross-sectional study was performed using biopsy records from a consortium of sixteen public OMPLs from all regions of Brazil (North, Northeast, Central-West, Southeast, and South). Clinical and demographic data of patients diagnosed with lip, oral cavity, and oropharyngeal SCC between 2010 and 2019 were collected from the patients' histopathological records.
View Article and Find Full Text PDFBackground: This study aimed to investigate the clinicopathological features of metastases in the oral and maxillofacial regions.
Methods: In this retrospective study, biopsy records were obtained from referral centers for oral and maxillofacial diagnosis in Brazil, Guatemala, Mexico, and South Africa.
Results: A total of 120 cases were evaluated.
The use of deep learning state-of-the-art architectures for oral epithelial dysplasia grading: A comparative appraisal.
J Oral Pathol Med
November 2023
Background: Dysplasia grading systems for oral epithelial dysplasia are a source of disagreement among pathologists. Therefore, machine learning approaches are being developed to mitigate this issue.
Methods: This cross-sectional study included a cohort of 82 patients with oral potentially malignant disorders and correspondent 98 hematoxylin and eosin-stained whole slide images with biopsied-proven dysplasia.
Background: Odontogenic tumors (OT) are composed of heterogeneous lesions, which can be benign or malignant, with different behavior and histology. Within this classification, ameloblastoma and ameloblastic carcinoma (AC) represent a diagnostic challenge in daily histopathological practice due to their similar characteristics and the limitations that incisional biopsies represent. From these premises, we wanted to test the usefulness of models based on artificial intelligence (AI) in the field of oral and maxillofacial pathology for differential diagnosis.
View Article and Find Full Text PDFLow-Grade Myofibroblastic Sarcoma of the Oral and Maxillofacial Region: An International Clinicopathologic Study of 13 Cases and Literature Review.
Head Neck Pathol
September 2023
Article Synopsis
- Low-grade myofibroblastic sarcoma (LGMS) is a rare tumor typically found in the oral cavity and head/neck region, characterized by myofibroblast cells and a high chance of returning locally but low risk of spreading to distant sites.
- The study analyzed 13 cases of LGMS from various countries, revealing that most patients are young females, often presenting with nodular lesions in the maxilla, and exhibiting specific microscopic and immunohistochemical features that confirm the diagnosis.
- Complete surgical removal of the tumor is recommended for treatment, but additional long-term studies are needed to better understand recurrence rates and metastasis potential.
Altered metabolic fingerprints of Diffuse large B-cell lymphoma, not otherwise specified (DLBCL NOS) may offer novel opportunities to identify new biomarkers and improve the understanding of its pathogenesis. This study aimed to investigate the modified metabolic pathways in extranodal, germinal center B-cell (GCB) and non-GCB DLBCL NOS from the head and neck. Formalin-fixed paraffin-embedded (FFPE) tissues from eleven DLBCL NOS classified according to Hans' algorithm using immunohistochemistry, and five normal lymphoid tissues (LT) were analyzed by high-performance liquid chromatography-mass spectrometry-based untargeted metabolomics.
View Article and Find Full Text PDFThe aim of this study was to describe the prevalence, clinicopathological, and prognostic features of acinic cell carcinoma (AciCC) of the oral and maxillofacial region. AciCC cases were retrospectively retrieved from 11 pathology centers of three different countries. Medical records were examined to extract demographic, clinical, pathologic, and follow-up information.
View Article and Find Full Text PDFBackground: Three years after the first confirmed COVID-19 case in Brazil, the outcomes of Federal government omissions in managing the crisis and anti-science stance heading into the pandemic have become even more evident. With over 36 million confirmed cases and nearly 700 000 deaths up to January 2023, the country is one of the hardest-hit places in the world. The lack of mass-testing programs was a critical broken pillar responsible for the quick and uncontrolled SARS-CoV-2 spread throughout the Brazilian population.
View Article and Find Full Text PDFClinical diagnostic approach for oral lymphomas: a multi-institutional, observational study based on 107 cases.
Oral Surg Oral Med Oral Pathol Oral Radiol
October 2023
Objective: To evaluate oral lymphomas' clinical manifestations and investigate whether clinical features are associated with lymphoma subtypes.
Study Design: Oral lymphomas with at least 1 representative clinical image were evaluated. They were classified according to their microscopic grade (high vs low), predominant cell size (small vs medium/large), and cellular lineage (B cell vs T cell).
Objective: Salivary gland tumors (SGT) are a diverse group of uncommon neoplasms that are rare in pediatric patients. This study aimed to characterize the clinicopathological profile of pediatric patients affected by SGT from a large case series derived from an international group of academic centers.
Study Design: A retrospective analysis of pediatric patients with SGT (0-19 years old) diagnosed between 2000 and 2021 from Brazil, South Africa, and the United Kingdom was performed.
Background: Subgemmal neurogenous plaques (SNP) are composed of neural structures found in the posterolateral portion of the tongue, rarely biopsied as most of them are asymptomatic or eventually only clinically managed. We aimed to investigate a case series of possible correlation of symptomatic subgemmal neurogenous plaque (SNP) with coronavirus disease 2019 (COVID-19).
Methods: Eleven formalin-fixed paraffin-embedded cases from patients with previous confirmed COVID-19 (by RT-PCR) were retrieved from two pathology files.
Radiological aspects of lymphomas and leukaemias affecting the jaws: A systematic review.
J Oral Pathol Med
April 2023
Background: This systematic review aimed to investigate the radiological features of lymphomas and leukaemias affecting the jaws.
Methods: A systematic literature review was conducted using the electronic databases of PubMed, Web of Science and Scopus. Articles that contained sufficient radiographic examinations (periapical, panoramic or computed tomography images) for individual cases were included.
The aim of this study is to report an original case series of synchronous jawbone diseases. Data of patients seen over 13 years were extracted from the files of three Oral Radiology and Pathology diagnostic centers in Brazil. The clinical, radiographic, and laboratory characteristics were tabulated and analyzed by the authors; the patients were described according to lesion type.
View Article and Find Full Text PDFDesmoplastic fibroma is a benign, rare, but locally aggressive lesion. The intraosseous type rarely presents in the jaws. Desmoplastic fibroma represents the intraosseous counterpart of the soft tissue fibromatoses or desmoid tumor, affects predominantly young people with an affinity for the mandible.
View Article and Find Full Text PDFMantle cell lymphoma involving the oral and maxillofacial region: a study of 20 cases.
Oral Surg Oral Med Oral Pathol Oral Radiol
January 2023
Objective: To investigate the clinicopathologic features of mantle cell lymphoma (MCL) involving the oral and maxillofacial region.
Methods: The MCL cases were retrieved from the pathosis database of 6 pathology laboratories. Original hematoxylin and eosin slides and immunohistochemical reactions were reviewed for confirmation of the initial diagnosis.
Background: Lymphomas affecting the sublingual glands are extremely rare and very few case reports are currently available. Therefore, the aim of the current study is to describe the clinicopathological features of a series of lymphomas involving the sublingual glands.
Methods: Cases diagnosed in four pathology services were assessed and the formalin-fixed paraffin-embedded tissue blocks were retrieved for diagnosis confirmation.
Molecular profile of head and neck rhabdomyosarcomas: A systematic review and meta-analysis.
Oral Surg Oral Med Oral Pathol Oral Radiol
September 2022
Objective: This systematic review aimed to identify the molecular alterations of head and neck rhabdomyosarcomas (HNRMS) and their prognostic values.
Study Design: An electronic search was performed using PubMed, Embase, Scopus, and Web of Science with a designed search strategy. Inclusion criteria comprised cases of primary HNRMS with an established histopathological diagnosis and molecular analysis.
Comparison of survival outcomes between ameloblastic carcinoma and metastasizing ameloblastoma: A systematic review.
J Oral Pathol Med
August 2022
Article Synopsis
- - The study aims to compare demographic data, recurrence rates, metastasis occurrences, and survival prognoses of ameloblastic carcinoma (AC) and metastasizing ameloblastoma (MA) using existing literature and diagnostics.
- - A total of 77 publications were reviewed, revealing that both tumors commonly appear in the mandible, but have differing profiles in terms of patient sex and age; however, survival rates between the two were similar despite MA patients living longer post-metastasis.
- - It was found that conservative treatments lead to more recurrences, particularly in MA patients, and that AC patients have a poorer prognosis compared to MA when metastasis occurs, indicating that conservative therapies should be avoided for both.