Reactive Oxygen Species and Mitochondrial Calcium's Roles in the Development of Atherosclerosis.

In the last decade, there has been increasing evidence connecting mitochondrial dysfunction to the onset and advancement of atherosclerosis. Both reactive oxygen species (ROS) and the disruption of mitochondrial calcium (Ca) regulation have garnered significant attention due to their involvement in various stages of atherosclerosis. This abstract discusses the potential therapeutic applications of targeting mitochondrial calcium (Ca) and reactive oxygen species (ROS), while also providing an overview of their respective roles in atherosclerosis.