Publications by authors named "Hekai Yu"
Objectives: To describe the prevalence, clinical characteristics and risk factors of liver steatosis and fibrosis in type 2 diabetes mellitus (T2DM) patients in eastern China.
Design: A cross-sectional, multicentre study based on an ongoing cohort study.
Setting: 16 clinics in eastern China, including primary clinics to tertiary hospitals.
Article Synopsis
- A multi-center study investigated liver conditions (steatosis and fibrosis) in patients with type 2 diabetes, specifically comparing lean individuals (BMI < 23 kg/m) to non-lean individuals (BMI ≥ 23 kg/m).
- The study included 1,762 participants and discovered that lean patients experienced higher rates of liver steatosis (44.7%) and fibrosis (23.4%) along with more hypertension and cardiovascular issues.
- Findings revealed that risk factors for liver steatosis vary significantly between lean and non-lean patients, suggesting the need for different management approaches based on body composition.
Background And Aims: Nonalcoholic fatty liver disease (NAFLD), currently referred to as metabolic dysfunction-associated steatotic liver disease (MASLD), affects approximately 38% of the world's population, yet no pharmacological therapies have been approved for treatment. We conducted a traditional and network meta-analysis to comprehensively assess the effectiveness of drug regimens on NAFLD, and continued to use the old terminology for consistency.
Methods: Randomized, placebo-controlled trials (RCTs) investigating drug therapy in an adult population diagnosed with NAFLD with or without diabetes mellitus were included.