Publications by authors named "Hekai Shi"
Purpose: Obesity is closely associated with a lower risk of inguinal hernia, but the association between different obesity metrics and the risk of inguinal hernia is still unclear.
Methods: In our study, we categorized obesity measurement indicators into three groups based on the difficulty of measurement: (1) indicators easily available, such as body mass index (BMI), waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR); (2) indicators accessible with moderate difficulty, such as body fat percentage and body fat mass; (3) indicators difficultly accessible, such as the volume of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). Mendelian randomization (MR) analysis was used to investigate the causal relationship between various adiposity measures and the risk of inguinal hernia in both European ancestry and East Asians.
Purpose: The systemic and local inflammatory response in patients after surgical operation is closely related to the quality of the wound healing. Low-quality wound healing and defects in the suture technique lead to the occurrence of incisional hernia (IH). However, the causal relationship between human circulating inflammatory cytokines, immune cell traits, and the risk of IH remains unclear.
View Article and Find Full Text PDFObjectives: Presbycusis, or age-related hearing loss (ARHL) has been a common disability disease among the elderly population. It is particularly essential to identify the underlying role of related risk factors for ARHL diagnosis and treatment. Observational studies have shown that cardiovascular disease may be a factor in ARHL.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to create and validate machine learning algorithms to predict surgical site infections (SSI) and surgical site occurrences (SSO) after elective open inguinal hernia surgery.
- Researchers analyzed data from 491 patients and used five different machine learning methods, finding the random forest model to be the most effective.
- The resulting predictive models identified key factors for SSI and SSO, and online calculators were created to help clinicians assess patient risk post-surgery.*
Article Synopsis
- The study addresses challenges in abdominal wall wound repair, focusing on issues like adhesion and infection post-surgery.
- A new bilayered composite patch was developed using advanced techniques, showing strong tensile, swelling, and degradation properties while also incorporating an antibacterial layer.
- The findings suggest that this composite patch not only enhances tissue repair and growth but also effectively prevents complications, indicating its potential for use in hernia repairs.
Purpose: Incisional hernia is a common postoperative complication; however, few transcriptomic studies have been conducted on it. In this study, we used second-generation high-throughput sequencing to explore the pathogenesis and potential therapeutic targets of incisional hernias.
Methods: Superficial fasciae were collected from 15 patients without hernia and 21 patients with an incisional hernia.
Four glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been used in children and adolescents with obesity or overweight. This network meta-analysis was conducted to compare the efficacy and safety of these regimens. Embase, PubMed, and Scopus were searched on March 2023 and updated in June 2024 for eligible randomized controlled trials (RCTs).
View Article and Find Full Text PDFObjectives: To determine the causal correlations of lifestyle behaviours and body fat distribution on diabetic microvascular complications through a Mendelian Randomization (MR).
Methods: Genetic variants significantly associated with lifestyle behaviours, abdominal obesity, generalized obesity and diabetic microvascular complications were extracted from the UK Biobank (UKB) and FinnGen. The inverse variance weighted (IVW) method was regarded as the primary method.
Background: Tirzepatide was approved to treat type 2 diabetes and obesity, but its efficacy and safety in patients without diabetes has not been investigated.
Aim: This meta-analysis aimed to evaluate the efficacy and safety of tirzepatide compared to placebo in overweight or obese patients without diabetes.
Method: PubMed, Embase and Cochrane were searched on January 18, 2024.
Parastomal hernias (PSH) are difficult to manage and associated with high rates of postoperative recurrence and complications. Sugarbaker and three-dimensional (3-D) mesh repair are commonly used methods for the surgical treatment of PSH. However, the efficacy and safety of these surgical techniques have not been adequately compared.
View Article and Find Full Text PDFBackground: This study aims to evaluate the efficacy and safety of vonoprazan-amoxicillin (VA), vonoprazan-amoxicillin-clarithromycin (VAC), vonoprazan-based bismuth-containing quadruple therapy (VBQT), and PPI-based triple (PAC) or quadruple therapy (PBQT) for H. pylori infection with the consideration of duration of therapy and amoxicillin dose (H: high; L: low).
Materials And Methods: PubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched for eligible randomized controlled trials (RCTs) up to December 15, 2023.
Article Synopsis
- The study aimed to identify risk factors for the recurrence of incisional hernias (IH) after open preperitoneal repair surgery.
- 145 patients treated for primary IH were included, and various perioperative factors were analyzed for their impact on hernia recurrence.
- Key findings revealed that pulmonary ventilation function abnormalities, age over 70, high BMI, and the use of certain mesh materials were significant independent predictors of IH recurrence.
Purpose: Ventral hernia (VH) is a common surgical disease. Previous studies suggested that obesity is an important risk factor for VH. However, the causal relationship between fat distribution and the risk of VH is still unclear.
View Article and Find Full Text PDFTension-free hernia repair is the gold standard for groin hernia repair. However, the optimal surgical treatment for incarcerated or strangulated groin hernia in elderly populations is controversial. The aim of this study is to compare the clinical efficacy of mesh repair and suture repair in the treatment of incarcerated or strangulated groin hernia in elderly patients.
View Article and Find Full Text PDFPurpose: To identify the prevalence of retinal pigment epithelium tear (RPET) after anti-vascular endothelial growth factor (VEGF) therapy and determine the efficacy of continued anti-VEGF therapy in patients with RPET.
Methods: All relevant clinical trials and observational studies in several online databases were screened. The main outcomes were the incidence of RPET after anti-VEGF therapy and changes in visual acuity for patients with RPET treated with continued anti-VEGF.
Article Synopsis
- - The study investigates the link between non-alcoholic fatty liver disease (NAFLD) and type-2 diabetes (T2DM), highlighting that hypoglycemic agents could potentially treat patients with both conditions, although no specific treatments are currently approved for NAFLD.
- - Researchers reviewed 19 random controlled trials from 2013 to 2023, evaluating the effectiveness and safety of twelve hypoglycemic treatments, using statistical measures like mean difference and SUCRA for ranking efficacy.
- - Findings suggest that a combination of insulin and GLP-1 receptor agonist (GLP1RA) is likely the best for weight loss, while thiazolidinediones (TZD) are effective for lowering HbA1
Background & Aim: We aimed to evaluate the efficacy and safety of probiotics and synbiotics in childhood functional constipation.
Methods: PubMed, Embase, Cochrane Library, ClinicalTrials.gov, and the International Clinical Trials Registry Platform (ICTRP) were searched up to June 2023.
The prevalence of myopic macular degeneration (MMD) in the general population and patients with high myopia worldwide has not been fully investigated. Therefore, we screened all population-based studies that reported the prevalence of MMD, and pooled prevalence of MMD using a random-effect model. Subgroup analyses were performed to explore the differences in MMD prevalence in the general population and patients with high myopia according to ethnicity, region of residence (urban/rural), and grading system.
View Article and Find Full Text PDFAim: To compare the efficacy and safety of synthetic and biological meshes in ventral hernia repair (VHR) and abdominal wall reconstruction (AWR).
Methods: We screened all clinical trials that reported the application of synthetic and biological meshes in VHR and AWR using Medline, Web of Science, and Embase (Ovid). Only comparative studies with similar baselines such as age, sex, body mass index, degree of wound contamination, and hernia defects between the intervention and control groups were included.
Article Synopsis
- -! The study aims to determine the best second-line treatment for patients with small-cell lung cancer who have previously responded to platinum-based chemotherapy, analyzing data from randomized controlled trials.
- Results show that triple chemotherapy with platinum (TP) had the highest objective response rate (ORR) and progression-free survival (PFS), although it also led to more severe side effects like anemia.
- Amrubicin is suggested as an alternative for those who can't handle the side effects of TP, as it offers a good balance of effectiveness and fewer hematological complications, while belotecan excelled in PFS.
The eradication of infection remains challenging due to increasing bacterial resistance. Resistance rates to clarithromycin, metronidazole, and levofloxacin were higher than 30% in the USA, making current therapies less effective. Vonoprazan triple therapy (VAC) has demonstrated similar efficacy and safety profiles compared to PPI-based triple therapy (PPI).
View Article and Find Full Text PDFBackground: The effect of antipsychotics on breast cancer remains controversial.
Materials And Methods: Embase, Scopus, PubMed, Web of Science, Cochrane Library, and Hebei Medical University Library were used for the literature search. Observational studies with original data for the effects of antipsychotics on breast cancer were used.
Article Synopsis
- The review aimed to clarify the relationship between hyperuricemia (HUA) and the risk of atrial fibrillation (AF) by analyzing existing clinical studies.
- Meta-analysis of data from over 600,000 participants indicated that individuals with hyperuricemia have a significantly higher risk of developing atrial fibrillation, with a risk ratio of 2.42.
- Sub-group analyses showed consistent findings across different countries, suggesting that managing hyperuricemia may reduce the risk of atrial fibrillation in patients.
Background And Purpose: Multiple guidelines suggest the ω-3 polyunsaturated fatty acids (ω-3 PUFAs) help to prevent major vascular events of coronary heart disease (CHD), but the data on large trials of ω-3 fatty acids are controversial. We reviewed the available evidence to determine the effect of ω-3 PUFAs on coronary atherosclerosis.
Materials And Methods: Literature were from online databases.