Publications by authors named "Hejia Xu"
J Transl Med
December 2024
Article Synopsis
- Colorectal cancer (CRC) shows resistance to immunotherapy, and m7G RNA modifications play a significant role in tumor growth and immune evasion.
- The study investigates how METTL1 influences m7G levels on PKM mRNA, leading to increased PKM2 protein expression and subsequent tumor progression through enhanced glycolysis and immune evasion mechanisms.
- Findings highlight METTL1 as a potential therapeutic target for CRC, suggesting that manipulating its signaling pathways could improve immunotherapy outcomes.
