Publications by authors named "Hejia Ge"
Neuropathic pain (NP) affects approximately 6.9-10% of the world's population and necessitates the development of novel treatments. Mitochondria are essential in the regulation of cell death.
View Article and Find Full Text PDFBackground: Conventional single indicators have low sensitivity and specificity for predicting weaning from mechanical ventilation in pediatric patients, necessitating the establishment of a combined prediction model for predicting weaning outcomes.
Objectives: To explore the combined predictive value of PaO/FiO Ratio (P/F ratio), diaphragm excursion-rapid shallow breathing index (DE-RSBI), diaphragm thickening fraction-rapid shallow breathing index (DTF-RSBI), and Pediatric Critical Illness Score (PCIS) in weaning from mechanical ventilation in pediatric patients.
Methods: Sixty critically ill pneumonia pediatric patients requiring mechanical ventilation treatment from July 2022 to June 2023 at the Second Affiliated Hospital of Jiaxing University were selected.
Recent studies have shown that peripheral nerve regeneration process is closely related to neuropathic pain. Toll-like receptor 4 (TLR4) signaling was involved in different types of pain and nerve regeneration. TLR4 induced the recruitment of myeloid differentiation factor-88 adaptor protein (MyD88) and NF-κB-depended transcriptional process in sensory neurons and glial cells, which produced multiple cytokines and promoted the induction and persistence of pain.
View Article and Find Full Text PDFArticle Synopsis
- Community-acquired bacterial meningitis (CABM) is a significant health issue in children, particularly in Zhejiang Province, with varied incidence and pathogen types based on age.
- A study analyzed 918 CABM cases from January 2019 to December 2020, revealing a relatively low annual incidence rate and a cure rate of 94.4%, though there was a notable economic burden and a 1.4% case fatality rate.
- Key pathogens identified were E. coli and GBS in infants under 3 months, while S. pneumoniae was the most common in older children, indicating a need for targeted prevention and treatment strategies.
Article Synopsis
- - This study focused on understanding factors that influence fever and the duration of fever in young children with bacterial meningitis (BM), involving data from 49 centers in China over a span of more than two years.
- - A total of 863 patients under three years old were analyzed, revealing that certain infections like coagulase negative staphylococcus led to less fever, while conditions such as septicaemia and ear-nose-throat infections were linked to higher fever rates.
- - The research identified specific factors associated with delayed fever resolution, including infections like Streptococcus agalactiae, gastrointestinal infections, and complications such as encephalomalacia and subdural effusion, which could help in diagnosing and monitoring the severity of the