The Farsi version of medication administration hassles scale in elderlies with chronic diseases: a psychometric study.

Background: Medication management is a crucial responsibility of family caregivers. Having a tool for assessing issues related to family caregiver medication prescription tasks is of great importance in evaluating the caregiving experience. This study aimed to translate and assess psychometrically the Medication Administration Hassles Scale in elderly individuals with chronic diseases.

Single-Walled Carbon Nanotube Probes for Protease Characterization Directly in Cell-Free Expression Reactions.

Proteins can be rapidly prototyped with cell-free expression (CFE) but in most cases there is a lack of probes or assays to measure their function directly in the cell lysate, thereby limiting the throughput of these screens. Increased throughput is needed to build standardized, sequence to function data sets to feed machine learning guided protein optimization. Herein, we describe the use of fluorescent single-walled carbon nanotubes (SWCNT) as effective probes for measuring protease activity directly in cell-free lysate.

Synergistic Interaction of Chloroquine with Semipolar Extract Against : Histopathological and Immunological Studies in a Mouse Model.

Background: Malaria parasites have gradually developed resistance to commonly used antimalarial drugs. For decades, chloroquine was the most widely used drug to eradicate malaria. However, with the spread of chloroquine resistance, many countries have adopted combination therapies that utilize two drugs acting synergistically instead of monotherapy.

Effect of health literacy-based teach-back training on quality of life and treatment adherence in type 2 diabetes: an experimental study.

Education for patients with type 2 diabetes is an essential part of the treatment and control process. This study aimed to determine the effect of education based on health literacy strategies on adherence to treatment and quality of life in type 2 diabetic patients. This classic experimental study was performed on 94 patients with type 2 diabetes selected by convenient sampling method and then randomly allocated to intervention and control groups.

The effect of silymarin on diabetes mellitus-induced male rats reproductive impairment: Evidences for role of heat shock proteins 70 and 90.

Male fertility is adversely influenced by diabetes. The beneficial effects of antioxidant bioflavonoids in improving fertility have been reported. This study was conducted to evaluate the effects of silymarin on diabetes mellitus-induced male reproductive impairment in rats by investigating its role in Hsp70 and Hsp90 expression.

Psychometric properties of the pain anxiety symptom scale among postoperative patients in Amol, Iran.

Introduction: So far, the psychometric properties of the Persian version of the Pain Anxiety Symptom Scale have not been assessed in Iran. Therefore, this study was conducted to determine the validity and reliability of the Persian version of the Pain Anxiety Symptom Scale among a group of Iranian patients in Amol.

Methods: This methodological study was conducted in 2023 with a sample of 400 postoperative patients from Amol, Iran, selected through convenience sampling.

Amplified DNA heterogeneity assessment with Oxford Nanopore sequencing applied to cell free expression templates.

In this work, Oxford Nanopore sequencing is tested as an accessible method for quantifying heterogeneity of amplified DNA. This method enables rapid quantification of deletions, insertions, and substitutions, the probability of each mutation error, and their locations in the replicated sequences. Amplification techniques tested were conventional polymerase chain reaction (PCR) with varying levels of polymerase fidelity (OneTaq, Phusion, and Q5) as well as rolling circle amplification (RCA) with Phi29 polymerase.

Therapeutic effect of topical tamoxifen in murine cutaneous leishmaniasis caused by .

Iran is one of the endemic regions of cutaneous leishmaniasis (CL) caused by . There is no protective vaccine available against CL available, and the most effective strategy is a definitive treatment. Topical medications can be an excellent option for this purpose.

The Interaction of Zinc as an Essential Trace Element with Parasites: A Systematic Review.

Background: The trace element of zinc (Zn) has shown great effectiveness in control of leishmaniasis infection. Hence, the present study conducted a systematic review of in vitro and in vivo studies evaluating the zinc effect in the treatment or prevention of leishmaniasis.

Materials And Methods: A systematic literature search was performed of all articles published in PubMed, SciELO, ScienceDirect, Scopus, Google Scholar, and Web of Science databases (1997-2023).

The Therapeutic Effect of Shirvan Herbal Ointment on Human Cutaneous Leishmaniasis Compared with Glucantime.

Background: Cutaneous leishmaniasis (CL) infection is caused by the parasite and affects 1.5 to 2 million people worldwide each year. Although research into vaccines and antiparasitic drugs has been somewhat successful, their adverse effects include high toxicity, prolonged regeneration, and scarring.

Characterizing the progression from mild cognitive impairment to dementia: a network analysis of longitudinal clinical visits.

Background: With the recent surge in the utilization of electronic health records for cognitive decline, the research community has turned its attention to conducting fine-grained analyses of dementia onset using advanced techniques. Previous works have mostly focused on machine learning-based prediction of dementia, lacking the analysis of dementia progression and its associations with risk factors over time. The black box nature of machine learning models has also raised concerns regarding their uncertainty and safety in decision making, particularly in sensitive domains like healthcare.

Epicatechin ameliorates glucose intolerance and hepatotoxicity in sodium arsenite-treated mice.

Arsenic is a metalloid found in the environment that causes toxic effects in different organs, mainly the liver. This study aimed to investigate the protective effects of epicatechin (EC), a natural flavonol, on glucose intolerance (GI) and liver toxicity caused by sodium arsenite (SA) in mice. Our findings showed that SA exposure led to the development of GI.

Experiences of family caregivers of individuals undergoing hemodialysis in Iran about caring during the COVID-19 pandemic: a qualitative study.

Background: The Coronavirus disease 2019 (COVID-19) pandemic has significantly affected various aspects of public health. The virus poses a particular threat to individuals with kidney failure undergoing hemodialysis and their caregivers. The present study investigated the experience of family caregivers of individuals undergoing hemodialysis about caring during the COVID-19 pandemic in Iran.

A validity and reliability evaluation of fear of progression questionnaire in Iranian breast cancer patients: A methodological study.

Background And Aims: Recognizing the ability to adapt coping mechanisms in response to the unique issues present in various Iranian societies underscores the importance of considering culture and religion when interacting with diverse groups of individuals. The objective of this study was to assess the reliability and validity of the fear of progression questionnaire-short form (FoP-Q-SF) in Iranian breast cancer patients.

Methods: In this methodological cross-sectional research design, 400 Iranian breast cancer patients completed the FoP-Q-SF in 2023.

Molecular docking and synthesis of N-alkyl-isatin-3-imino aromatic amine derivatives and their antileishmanial and cytotoxic activities.

Background And Purpose: Isatin derivatives have excited attention due to their biological attractions, especially, anticancer properties. Isatin analogs such as semaxanib and sunitinib were exposed to tyrosine kinase inhibitory properties. N-substituted isatins were reported to show cytotoxic activity.

Chitosan/poly-γ-glutamic acid crosslinked hydrogels: Characterization and application as bio-glues.

Ecofriendly hydrogels were prepared using chitosan (CH, 285 kDa) and two fractions of low molecular weight microbial poly-γ-glutamic acid (γ-PGA) (R1 and R2 of 59 kDa and 20 kDa, respectively). The hydrogels were synthesized through sustainable physical blending, employing three CH/γ-PGA mass ratios (1/9, 2/8, and 3/7), resulting in the formation of physically crosslinked materials. The six resulting CH/R1 and CH/R2 hydrogels were physico-chemically characterized and the ones with the highest yields (CH/R1 and CH/R2 ratio of 3/7), analyzed for rheological and morphological properties, showed to act as bio-glues on wood and aluminum compared to commercial vinyl- (V1) and acetovinyl (V2) glues.

Comparing the effects of pre-emptive oxycodone, diclofenac, and gabapentin on postoperative pain after tibia fracture surgery: A randomized clinical trail.

Background: Postoperative pain (POP) is one of the most common and most important types of pain.

Objectives: The aim of this study was to compare the effects of pre-emptive oxycodone, diclofenac, and gabapentin on postoperative pain (POP) among patients with tibia fracture surgery.

Materials And Methods: This double-blind three-group randomised controlled trial was conducted in 2023.

Growth language mindset and willingness to communicate: Contributions of linguistic risk taking and learning experience.

As various contextual and individual difference factors determine how and when mindsets may influence learning outcomes, burgeoning L2 research has recently addressed the role of growth language mindset (GLM) in different learning outcomes such as L2 Willingness to Communicate (WTC). Since little is known about the underlying mechanism through which GLM may contribute to WTC, a highly desirable goal of L2 education and an important criterion for assessing its efficiency and success, the present study addresses this gap by investigating the possible mediating and moderating roles of linguistic risk taking and L2 learning experience, respectively. The participants were 392 Iranian L2 students chosen by multi-stage cluster sampling.

Amplified DNA Heterogeneity Assessment with Oxford Nanopore Sequencing Applied to Cell Free Expression Templates.

In this work, Oxford Nanopore sequencing is tested as an accessible method for quantifying heterogeneity of amplified DNA. This method enables rapid quantification of deletions, insertions, and substitutions, the probability of each mutation error, and their locations in the replicated sequences. Amplification techniques tested were conventional polymerase chain reaction (PCR) with varying levels of polymerase fidelity (OneTaq, Phusion, and Q5) as well as rolling circle amplification (RCA) with Phi29 polymerase.

The Farsi version of Caregiver Preparedness Scale in Iranian family caregivers of the older adults undergoing hemodialysis: a psychometric study.

Background: Enhancing preparedness of family caregivers and support for caregiving is essential for the mutual benefit of both caregivers and the well-being of those under their care. This study aimed to translate and evaluate psychometric properties of the Caregiver Preparedness Scale among family caregivers of older adults undergoing hemodialysis.

Methods: In this methodological study, 400 family caregivers of older adult patients undergoing hemodialysis enrolled to the study via convenience sampling method.