Adipocytes from women with polycystic ovary syndrome demonstrate altered phosphorylation and activity of glycogen synthase kinase 3.

Objective: To test the hypothesis that an abnormality in glycogen synthase kinase-3 (GSK3) is a pathogenic factor in polycystic ovary syndrome (PCOS).

Design: Prospective experimental study (adipocytes).

Setting: Tertiary-care academic medical center and teaching hospital.