Expression and alpha1-adrenoceptor regulation of caldesmon in human prostate smooth muscle.

Objective: To investigate expression and α1-adrenergic regulation of caldesmon in the human prostate. Caldesmon is an important mediator and regulator of contraction in different smooth muscle types. However, this has not been investigated in the prostate to date.

[Establishment of T3 (T4) in the TNM classification of lung cancer].

The diagnosis of T3 (T4) extension of a lung tumor according to the TNM classification system means that the patient has reached stage 3 with a very poor prognosis. To establish the exact extent of a tumor standard chest X-rays, tomograms and even CT scan may not suffice, and, depending on the situation, endoscopy, ultrasonography, NMR or diagnostic pneumothorax should be employed. Extension T4, corresponding to malignant pleural effusion, which has been added recently (1987) to the UICC classification, may require thoracocentesis, pleural biopsy or even pleuroscopy.

[Comparative study of the effects of regular or on-demand salbutamol inhalation in the treatment of asthma].

52 asthmatic patients aged 18 to 70 years took part in a double-blind crossover trial comparing the effects of regular treatment of asthma with inhaled salbutamol (400 micrograms qds) versus irregular treatment (400 micrograms prn), each prescribed for 4 weeks. There were no differences between the two schedules regarding intensity of clinical symptoms, morning and evening values of peak expiratory flow rates and spirometric measurements. The mean daily consumption of salbutamol was higher in the period of regular treatment (2148 +/- 548 micrograms) than in the period of free treatment (800 +/- 700 micrograms).

[Initial reduction of the lung volume and capillary escape syndrome in gram negative peritonitis].

Report on a female patient aged 29 with gramnegative bacterial peritonitis due to perforation of a postpyloric ulcer. A reduction of lung volume was observed, followed after 24 h by non cardiogenic interstitial and alveolar edema resulting in severe hypoxemia and hypercapnia with metabolic acidosis for 4 days. Return of gas exchange to physiological values was established prior to the restoration of normal lung volume.

[Early diagnosis of lung cancer].

268 patients with suspected lung cancer were examined over the period 1 January 1972 to 31 May 1974. On the basis of the 735 investigations performed, a 6-8 h workup program has been established including physical and functional examination, standard X-rays and hilar tomography, endoscopy and biopsy for cytologic or histologic study. Several biopsy technics are described and their indications tabulated according to their efficiency in relation to the radiologic aspect of the lesion.