Artificial intelligence in the care of children and adolescents with chronic diseases: a systematic review.

Unlabelled: The integration of artificial intelligence (AI) and machine learning (ML) has shown potential for various applications in the medical field, particularly for diagnosing and managing chronic diseases among children and adolescents. This systematic review aims to comprehensively analyze and synthesize research on the use of AI for monitoring, guiding, and assisting pediatric patients with chronic diseases. Five major electronic databases were searched (Medline, Scopus, PsycINFO, ACM, Web of Science), along with manual searches of gray literature, personal archives, and reference lists of relevant papers.

Parent Outreach Efforts Extend the Sustained Benefits of a Preschool Classroom Intervention: Adolescent Follow-Up of a Randomized Controlled Trial.

The Research-based Developmentally Informed (REDI) program enriched Head Start classrooms with teacher-delivered curriculum components designed to enhance child social-emotional learning and language-literacy skills. Parents received information about the program via backpack express, including weekly handouts about program topics and three DVDs illustrating REDI interactive strategies and suggesting home learning activities. In addition to effects on child skill acquisition and school performance (reported previously), positive effects emerged on a family-based outcome: parents of children in REDI-enriched classrooms reported higher quality preschool parent-child conversations than parents in the randomized control group (usual practice) classrooms.

Green Chemistry for the Transformation of Chlorinated Wastes: Catalytic Hydrodechlorination on Pd-Ni and Pd-Fe Bimetallic Catalysts Supported on SiO.

Monometallic catalysts based on Fe, Ni and Pd, as well as bimetallic catalysts based on Fe-Pd and based on Ni-Pd supported on silica, were synthesized using a sol-gel cogelation process. These catalysts were tested in chlorobenzene hydrodechlorination at low conversion to consider a differential reactor. In all samples, the cogelation method allowed very small metallic nanoparticles of 2-3 nm to be dispersed inside the silica matrix.

Learning to Live with Strange Error: Beyond Trustworthiness in Artificial Intelligence Ethics.

Position papers on artificial intelligence (AI) ethics are often framed as attempts to work out technical and regulatory strategies for attaining what is commonly called In such papers, the technical and regulatory strategies are frequently analyzed in detail, but the concept of trustworthy AI is not. As a result, it remains unclear. This paper lays out a variety of possible interpretations of the concept and concludes that none of them is appropriate.

Ethical Implications of e-Health Applications in Early Preventive Healthcare.

As a means of preventive medicine early detection and prevention examinations can identify and treat possible health disorders or abnormalities from an early age onwards. However, pediatric examinations are often widely spaced, and thus only snapshots of the children's and adolescents' developments are obtained. With e-health applications parents and adolescents could record developmental parameters much more frequently and regularly and transmit data directly for ongoing evaluation.

Advance research directives: avoiding double standards.

Background: Advance research directives (ARD) have been suggested as a means by which to facilitate research with incapacitated subjects, in particular in the context of dementia research. However, established disclosure requirements for study participation raise an ethical problem for the application of ARDs: While regular consent procedures call for detailed information on a specific study ("token disclosure"), ARDs can typically only include generic information ("type disclosure"). The introduction of ARDs could thus establish a double standard in the sense that within the context of ARDs, type disclosure would be considered sufficient, while beyond this context, token disclosure would remain necessary.

[The predictable human : Possibilities and risks of AI-based prediction of cognitive abilities, personality traits and mental illnesses].

New approaches to the use of artificial intelligence (AI) to analyze data from neuroimaging but also passively collected data from so-called wearables, such as smartphones or smartwatches, as well as data that can be extracted from social media and other online activities, already make it possible to predict cognitive abilities, personality traits, and mental illnesses, as well as to reveal acute mental states. In this article, we explain the methodological concepts behind these current developments, illuminate the possibilities and limitations, and address ethical and social aspects arising from the use.

The Potential Effect of Na 1.8 in Autism Spectrum Disorder: Evidence From a Congenital Case With Compound Heterozygous Mutations.

Apart from the most prominent symptoms in Autism spectrum disorder (ASD), namely deficits in social interaction, communication and repetitive behavior, patients often show abnormal sensory reactivity to environmental stimuli. Especially potentially painful stimuli are reported to be experienced in a different way compared to healthy persons. In our present study, we identified an ASD patient carrying compound heterozygous mutations in the voltage-gated sodium channel (VGSC) Na 1.

Sustained Benefits of a Preschool Home Visiting Program: Child Outcomes in Fifth Grade.

This study evaluated the sustained effects of the Research-based Developmentally Informed Parent program (REDI-P) at fifth grade, six years after intervention. Participants were 200 prekindergarten children attending Head Start (55% White, 26% Black, 19% Latinx, 56% male, mean age of 4.45 years at study initiation) and their primary caregivers, who were randomly assigned to a control group or a 16-session home-visiting intervention that bridged the preschool and kindergarten years.

Moral ambivalence. A comment on non-invasive prenatal testing from an ethical perspective.

Background: Non-invasive prenatal testing (NIPT) has been available for almost 10 years. In many countries the test attracted considerable criticism from the start. While most critical comments in this context deal with the (alleged) problem of eugenic selection, I will concentrate on a somewhat broader issue.

Limiting total mixed ration availability alters eating and rumination patterns of lactating dairy cows.

The objective of this study was to investigate the effect of restricting total mixed ration (TMR) eating time with or without supplemental long hay offered on diurnal total intake, rumination, and rumen pH patterns in mid-lactation dairy cows. Eight multiparous Holstein cows were used in a replicated 4 × 4 Latin square design study with 21-d periods. The basal diet was the same for all 4 treatments with or without additional long grass hay (the same hay used in the TMR).

Significantly enhancement of sunlight photocatalytic performance of ZnO by doping with transition metal oxides.

In this study we report, the synthesis of ZnO and its doping with Transition Metal Oxides -TMO-, such as CrO, MnO, FeO, CoO, NiO, CuO and CuO. Various characterization techniques were employed to investigate the structural properties. The X-ray diffraction (XRD) data and Rietveld refinement confirmed the presence of TMO phases and that the ZnO structure was not affected by the doping with TMO which was corroborated using transmission Electron microscopy (TEM).

Marine Spatial Planning in the Benguela Current Large Marine Ecosystem.

The Benguela Current Large Marine Ecosystem (BCLME) in the south-east Atlantic covers the territorial waters and Exclusive Economic Zones (EEZ's) of Angola and Namibia and partly of South Africa. Increasing demands, user-user and user-environment conflicts occur throughout the area. The three countries, which are parties to the Benguela Current Convention (BCC), have begun to implement Marine Spatial Planning (MSP) to support the sustainable development of the area and enhance ocean governance.

Reducing Adolescent Psychopathology in Socioeconomically Disadvantaged Children With a Preschool Intervention: A Randomized Controlled Trial.

Objective: Living in poverty increases exposure to adversities that undermine healthy development, impeding growth in the social-emotional and language skills that support adaptive coping and promote mental health. Evidence-based programs have the potential to improve current preschool practice and strengthen these early skills, potentially reducing risk for later psychopathology. The authors tested the hypothesis that an enrichment program in preschool would be associated with reduced levels of psychopathology symptoms at the transition from middle to secondary school.

Promoting resilience: A preschool intervention enhances the adolescent adjustment of children exposed to early adversity.

Two hundred ninety-four children from low-income families (58% White, 17% Latinx, 25% Black; 54% girls; Mage = 4.49 years old at study entry) were recruited from Head Start classrooms to participate in a randomized-controlled trial of the project Research-based, Developmentally Informed (REDI) preschool intervention and then followed longitudinally for 10 years through 9th grade. At study entry, parents reported on their children's exposure to adverse childhood experiences (ACEs).

Longitudinal Associations Linking Elementary and Middle School Contexts with Student Aggression in Early Adolescence.

Growing up in poverty increases youth risk for developing aggressive behavior problems, which, in turn, are associated with a host of problematic outcomes, including school drop-out, substance use, mental health problems, and delinquency. In part, this may be due to exposure to adverse school contexts that create socialization influences supporting aggression. In the current study, 356 children from low-income families (58% White, 17% Latinx, 25% Black; 54% girls) were followed from preschool through seventh grade.

Au nanobipyramids@mSiO core-shell nanoparticles for plasmon-enhanced singlet oxygen photooxygenations in segmented flow microreactors.

The plasmonic features of gold nanomaterials provide intriguing optical effects which can find potential applications in various fields. These effects depend strongly on the size and shape of the metal nanostructures. For instance, Au bipyramids (AuBPs) exhibit intense and well-defined plasmon resonance, easily tunable by controlling their aspect ratio, which can act synergistically with chromophores for enhancing their photophysical properties.

Sustained effects of a school readiness intervention: 5th grade outcomes of the Head Start REDI program.

This study examined the sustained effects of the Head Start Research-based Developmentally Informed (REDI) program, which enriched preschools with evidence-based programming targeting social-emotional and language/emergent literacy skills. 44 Head Start classrooms were randomly assigned to intervention or a usual practice control group, and 356 4-year-olds (25% African American, 17% Latino, 54% female) were followed through the end of 5th grade. Growth curve analyses revealed that significant intervention effects on teacher-rated social adjustment, academic engagement, and parent involvement identified at the end of the Head Start year were sustained throughout elementary school.

Your evidence? Machine learning algorithms for medical diagnosis and prediction.

Computer systems for medical diagnosis based on machine learning are not mere science fiction. Despite undisputed potential benefits, such systems may also raise problems. Two (interconnected) issues are particularly significant from an ethical point of view: The first issue is that epistemic opacity is at odds with a common desire for understanding and potentially undermines information rights.

Motor vehicle crash reconstruction: Does it relate to the heterogeneity of whiplash recovery?

Whiplash injury is a common consequence of motor vehicle crashes (MVC), yet it is also one of the most poorly understood. While more than 50% of those injured should expect to rapidly recover, others are not as fortunate with approximately 25% of those exposed to and injured in an MVC transitioning from acute to chronic pain and disability. The purpose of this prospective study was to determine if the severity and direction of collisions involving participants enrolled in a longitudinal study of recovery from whiplash are able to differentiate between different recovery groups based on the neck disability index (NDI) percentage scores at 3-months, and if these crash specific parameters are associated with known risk factors for recovery.

Heterogeneous singlet oxygen generation: in-operando visible light EPR spectroscopy.

The use of photosensitizers immobilized on mesoporous materials to produce singlet oxygen (O) has opened a new way to synthetic and environmental applications due to the fast development of flow photochemistry and continuous-flow microreactors. O-based photosensitized processes can be employed for the degradation of organic pollutants in an aqueous medium and the photosensitizer can be covalently attached to the support and separated from the effluent reducing the environmental impact. The aim of the present paper is to evaluate the O generation of Rose Bengal (RB) in homogeneous and heterogeneous systems using in-operando evaluation.

Fecal particle dry matter and fiber distribution of heifers fed ad libitum and restricted with low and high forage quality.

Wet sieving of manure can be used as a means of evaluating the nutrient utilization of diets by dairy cows. A commercially available system for this analysis (Nasco Digestion Analyzer, Nasco, Fort Atkinson, WI; NDA) employs principles of wet sieving for on-farm assessment. The objective of this study was to evaluate effects of diet manipulations and sampling techniques on fecal particle dry matter (DM), neutral detergent fiber (NDF), and starch distribution on NDA sieves.

Myth or Magic? Towards a Revised Theory of Informed Consent in Medical Research.

Although the principle of informed consent is well established and its importance widely acknowledged, it has met with criticism for decades. Doubts have been raised for a number of different reasons. In particular, empirical data show that people regularly fail to reproduce the information provided to them.

Effect of Preschool Home Visiting on School Readiness and Need for Services in Elementary School: A Randomized Clinical Trial.

Importance: Home visiting programs targeting the school readiness of preschool children (age range, 4-5 years) show promise in short-term and quasi-experimental studies but rarely are evaluated with rigorous designs and follow-up assessments.

Objectives: To examine the sustained effects of a preschool home visiting program on child and family competencies and on child need for services 4 years later.

Design, Setting, And Participants: In a randomized clinical trial, individual families with preschool children were assigned to receive the Research-Based and Developmentally Informed-Parent home visiting program (REDI-P) (intervention group) or math home learning games in the mail (control group).

Working with Research Integrity-Guidance for Research Performing Organisations: The Bonn PRINTEGER Statement.

This document presents the Bonn PRINTEGER Consensus Statement: Working with Research Integrity-Guidance for research performing organisations. The aim of the statement is to complement existing instruments by focusing specifically on institutional responsibilities for strengthening integrity. It takes into account the daily challenges and organisational contexts of most researchers.