Publications by authors named "Heinrich Neubauer"
Article Synopsis
- The study analyzed 49 strains of a common hospital pathogen from humans, dogs, and cats using NGS technology, revealing that standard identification methods (MALDI-TOF) were inadequate for some newly discovered isolates.* -
- Notably, different sequence types were identified among the strains, with human isolates showing higher resistance to multiple antibiotics, including extensive drug-resistant types, whereas animal isolates were generally less resistant.* -
- The research indicated inconsistencies between observed resistance patterns and genetic data, suggesting a need for more extensive studies to understand antimicrobial resistance across various sources, highlighting the importance of a One Health approach in monitoring infections in Egypt.*
Tritrichomonas foetus is a parasitic protist responsible for bovine trichomonosis, a reproductive disease associated with significant economic burden to the livestock industry throughout the world. Here, we present a chromosome-level reference genome of T. foetus -KV-1 (ATCC 30924) using short-read (Illumina Miseq), long-read (Oxford Nanopore) and chromatin-linked (Hi-C) sequencing.
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- Brucellosis is a sickness caused by bacteria that affects both people and animals, causing health problems and money loss in farming in Türkiye and other countries.
- Researchers studied the genes of 106 samples from animals and humans in Türkiye to understand how they differ from each other and from samples in other countries.
- The study found different types of the bacteria in Türkiye, showing they are also related to bacteria from neighboring countries and some European countries, which means travel might help spread the disease, so better controls are needed to keep it from spreading.
Article Synopsis
- The study aimed to characterize antimicrobial resistance (AMR) data in veterinary medicine by analyzing minimum inhibitory concentrations (MICs) of various antimicrobial agents and the techniques used for testing.
- A systematic review was conducted using three scientific databases, focusing on studies related to AMR in different animal species and employing specific susceptibility testing methods.
- Out of 1582 studies identified, only 80 were analyzed, revealing that Europe and North America have the most research activity, particularly involving production animals and pets, with significant diversity in MICs across species.
Article Synopsis
- The study focuses on ribotype (RT) 002, linked to severe healthcare-associated infections like colitis, by analyzing the genetic characteristics of 537 genomes associated with MLST sequence type (ST) 8.
- Researchers sequenced 298 strains from a new European collection, comparing them with a global dataset of 1,437 ST8 genomes, revealing genetic similarity, diverse antimicrobial resistance genes, and an open genomic structure.
- Results indicate that while ST8 shows low overall variation and stability across different environments, it can still acquire antimicrobial resistance genes, highlighting the need for ongoing surveillance of non-human sources to better understand its epidemiology.
Q fever, a worldwide-occurring zoonotic disease, can cause economic losses for public and veterinary health systems. Vaccines are not yet available worldwide and currently under development. In this regard, it is important to produce a whole cell antigen, with preserved structural and antigenic properties and free of chemical modifications.
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- - Pseudomonas aeruginosa (P. aeruginosa) is a bacteria that can quickly become resistant to antibiotics, posing a major threat to public health and the poultry industry in Egypt, leading to significant economic losses due to its presence in farms. - A study analyzed 38 isolates from broiler farms using whole genome sequencing (WGS), revealing that all isolates were resistant to fosfomycin and exhibited a variety of antimicrobial resistance (AMR) genes, with some evidence of genetic diversity among the strains. - The presence of multiple AMR and virulence-associated factors in P. aeruginosa from poultry farms underscores the importance of responsible antibiotic use and raises concerns about the implications for food safety and public health.
Contagious bovine genital campylobacteriosis (BGC), also known as bovine venereal campylobacteriosis, is a disease relevant to international trade listed by the World Organization for Animal Health (WOAH). It is caused by subsp. (), one of three subspecies of .
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- - The study investigates genetic diversity and antibiotic resistance in bacteria causing bovine mastitis, a disease that leads to significant economic losses in dairy farming, particularly focusing on isolates from 17 farms in Thuringia, Germany.
- - Out of 40 collected isolates, 75% were found to be methicillin-resistant, showing high resistance rates against several antibiotics like penicillin and tetracycline, while exhibiting susceptibility to others like linezolid and vancomycin.
- - The isolates were categorized into five sequence types, with the majority being ST398, and shared resistance genes linked to antibiotic resistance, highlighting the need for targeted interventions in dairy farming practices.
Article Synopsis
- - Brucellosis, caused by Brucella spp., is a disease prevalent in Greece, but cases are likely under-reported, and there's limited knowledge about the genetic diversity of the bacteria.
- - Researchers sequenced the genomes of 44 Brucella isolates from humans and animals in Greece, revealing various sublineages, including a novel subgenotype linked to Greek strains, with most isolates believed to have local origins.
- - The study highlights the presence of multiple persistent Brucella foci in Greece and emphasizes the need for improved sampling efforts to better track and understand outbreaks of the disease.
Abortion is one of the leading causes of economic losses in the livestock industry worldwide. , , and spp. are the leading cause of late fetal loss in small ruminants.
View Article and Find Full Text PDF() is a highly problematic pathogen with an enormous capacity to acquire or upregulate antibiotic drug resistance determinants. The genomic epidemiology and resistome structure of 46 clinical isolates were studied using whole-genome sequencing. The isolates were chosen based on reduced susceptibility to at least three classes of antimicrobial compounds and were initially identified using MALDI-TOF/MS, followed by polymerase chain reaction amplification of genes.
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- Anthrax is a serious infectious disease affecting livestock and wildlife, considered a potential bioterrorism threat.
- From 2005 to 2022, Europe reported 267 anthrax cases, primarily in domestic animals, with notable occurrences in Albania, Russia, and Italy, while Ukraine has sporadic infections mostly detected in soil.
- The presence of burial sites from cattle and a need for further research on anthrax in wildlife, along with genetic and virulence studies, are crucial for improving awareness and response measures in affected regions.
Article Synopsis
- - Salmonella infections are a major public health concern, particularly in Sub-Saharan Africa, where some non-typhoidal serovars are linked to severe diseases in children; this study focused on identifying and analyzing these resistant and virulent strains in Nigeria.
- - Over a period from December 2017 to May 2019, researchers collected 2,522 samples from humans, animals, and the environment, followed standard microbiological methods for analysis, and conducted antibiotic susceptibility testing and whole genome sequencing (WGS) for deeper insights.
- - The study isolated 48 non-typhoidal Salmonella strains, with varying prevalence rates, identified several serovars, and found that all isolates possessed multiple antibiotic resistance and
The increasing incidence of extended-spectrum β-lactamase (ESBL)-producing (.) in backyard chicken farming in Pakistan is of serious concern. This study aimed to assess the prevalence, antimicrobial resistance patterns and risk factors associated with ESBL avian pathogenic (APEC) isolated from backyard chickens in the Jhang district, Punjab, Pakistan.
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- - The study focused on the zoonotic bacterium's epidemiology and genetic variation from turkey farms in Germany, utilizing whole-genome sequencing to analyze 66 isolates collected from meat turkey flocks between 2010 and 2011.
- - Researchers identified 28 different genetic types and found significant genetic diversity among the isolates, with various resistance and virulence genes associated with diseases and antibiotic resistance being characterized through advanced bioinformatics tools.
- - Key findings included the detection of multiple resistance genes, including those linked to ampicillin and tetracycline, as well as a mutation associated with fluoroquinolone resistance, highlighting public health implications due to the observed genetic resistance patterns.
Article Synopsis
- - The text discusses bovine genital campylobacteriosis (BGC), a disease causing major reproductive issues in cattle and recognized by the World Organization for Animal Health, leading to economic challenges and strict control measures in various countries.
- - A study conducted in Germany analyzed 63 BGC strains collected over 30 years using whole-genome sequencing, revealing a genetically conserved population with geographical clusters.
- - Results indicate that BGC control efforts in Germany have been effective, with no reported outbreaks since 2015, and suggest that the German strains share a common lineage that likely originated in the 19th century.
Article Synopsis
- - Brucellosis, a widespread zoonotic disease in Iran, shows significant antimicrobial resistance (AMR) among isolates from humans and animals, raising health concerns.
- - The study identified common Brucella species in various animal hosts and found resistance patterns to certain antibiotics, but whole genome sequencing (WGS) did not reveal classical AMR genes.
- - Despite being susceptible to most antibiotics, the lack of identified classical AMR genes in resistant strains suggests a need for further investigation into resistance mechanisms at the protein and RNA levels.
Little is known about zoonotic pathogens and their antimicrobial resistance in South American camelids (SAC) in Germany including (.) . The aim of this study was to investigate prevalence, molecular characteristics and antimicrobial resistance of in SAC.
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- * A study analyzed 40 strains of Brucella collected from animals and humans across 13 Iranian provinces (2015-2020) using advanced genome sequencing techniques to understand their genetic relationships and origins.
- * Findings showed that Iranian strains are related to American and Mediterranean lineages, with notable similarities to strains from neighboring countries, emphasizing the need for targeted brucellosis control measures through a One-Health approach.
Article Synopsis
- * All strains were classified as ST16 with 43 virulence factors identified, and they were grouped into a complex type showing low diversity, suggesting a single introduction to the region.
- * Comparison with 92 global B. suis genomes indicated the need for further investigation across different Egyptian areas to prevent the spread of the bacteria.
Article Synopsis
- Brucellosis, primarily spread through unpasteurized dairy and contact with infected animals, is widespread in Kyrgyzstan, but the source and diversity of Brucella in humans are not well understood.
- Researchers collected 89 Brucella isolates from suspected cases across Kyrgyzstan between 2019-2020, using advanced sequencing and genotyping techniques to analyze their genetic diversity and relationships.
- The study identified B. melitensis as the main strain causing human brucellosis in Kyrgyzstan, discovering multiple lineages that align closely with strains from neighboring countries; further research on animal populations is necessary for a complete understanding of the disease's dynamics.