Is cardiopulmonary transit time (CPTT) measured by using dynamic rubidium cardiac PET/CT a predictor for cardiac function?

Cardiopulmonary transit time (CPTT) represents the time needed for the circulation of blood from the right to the left ventricle. This parameter can be measured during dynamic acquisition of rubidium ([Rb]) cardiac PET/CT. To further characterize this marker, we wanted to assess the association between CPTT and parameters of cardiac function derived from echocardiography.

Improved Image Quality Through Deep Learning Acceleration of Gradient-Echo Acquisitions in Uterine MRI: First Application with the Female Pelvis.

Rationale And Objectives: The aim of this study was to compare the image quality of a deep learning (DL)-accelerated volumetric interpolated breath-hold examination (VIBE) sequence with a standard (ST) VIBE sequence in assessing the uterus.

Materials And Methods: Between April and December 2023, a total of 61 female patients (aged 41 ± 14 years) who were referred for an magnetic resonance imaging (MRI) of the pelvis were included in this prospective study, after providing informed consent. All examinations were performed with a 1.

How Prostate Cancer Growth Patterns Impact Detection and Interreader Agreement on Multiparametric MRI.

Rationale And Objectives: Multiparametric MRI (mpMRI) substantially improves the detection of significant prostate carcinoma (PCa) compared to systematic biopsy. Nevertheless, mpMRI can overlook aggressive forms of PCa. Recent studies showed, that infiltrative growth (INF) has less restricted diffusion.

Quantification of [Tc]Tc-HDP bone SPECT/CT: can we improve the body weight based standardized uptake value with a more robust normalization?

Background: The introduction of quantitative SPECT/CT allows more objective assessments of tracer accumulation in SPECT. However standardized uptake values (SUV) still do not play a big role for orthopedic or oncologic questions. With a more reliable normalization, the use of quantitative measures might also be of use for a more objective assessment of lesions.

Smooth Operator: Nanotextured Breast Tissue Expanders Are Associated with Lower Rates of Capsular Contracture.

Continuous research on breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) has introduced a focus on surface texturizations and a shift towards smooth breast devices, yet outcomes comparing the complication profiles of differently textured tissue expanders (TEs) remain conflicting. The study aim was to compare the complication profile of a new nanotextured and MRI-compatible TE to micro- and macrotextured TEs and to identify possible predictors for complications. A retrospective analysis of women undergoing expander-based breast reconstruction after mastectomy between January 2016 and March 2022 was conducted.

Immunohistochemical ERG positivity is associated with decreased PSMA expression and lower visibility in corresponding [Ga]Ga-PSMA-11 PET scans of primary prostate cancer.

Purpose: TMPRSS2:ERG gene fusion negatively regulates PSMA expression in prostate adenocarcinoma (PCa) cell lines. Therefore, immunohistochemical (IHC) ERG expression, a surrogate for an underlying ERG rearrangement, and PSMA expression patterns in radical prostatectomy (RPE) specimens of primary PCa, including corresponding PSMA-PET scans were investigated.

Methods: Two cohorts of RPE samples (total n=148): In cohort #1 (n=62 patients) with available RPE and preoperative [Ga]Ga-PSMA-11 PET, WHO/ISUP grade groups, IHC-ERG (positive vs.

In situ temperature determination using magnetic resonance spectroscopy thermometry for noninvasive postmortem examinations.

Magnetic resonance spectroscopy (MRS) thermometry offers a noninvasive, localized method for estimating temperature by leveraging the temperature-dependent chemical shift of water relative to a temperature-stable reference metabolite under suitable calibration. Consequentially, this technique has significant potential as a tool for postmortem MR examinations in forensic medicine and pathology. In these examinations, the deceased are examined at a wide range of body temperatures, and MRS thermometry may be used for the temperature adjustment of magnetic resonance imaging (MRI) protocols or for corrections in the analysis of MRI or MRS data.

Prolonged diacetylmorphine take-home during the COVID-19 pandemic-Results of a retrospective cohort study.

Background And Aims: Legal regulations for dispensing in Swiss heroin-assisted treatment were relaxed during the COVID-19 pandemic, allowing prolonged take-home of up to 7 days instead of two to reduce patient contact and the risk of infection. Our study aimed to measure the consequences of this new practice.

Design, Setting And Participants: This was a retrospective cohort study set in Switzerland's largest outpatient centre for opioid agonist therapy.

Evaluating the biodistribution for [Ga]Ga-PSMA-11 and [F]F-PSMA-1007 PET/CT with an inter- and intrapatient based analysis.

Background: Liver uptake in [Ga]Ga-PSMA-11 PET is used as an internal reference in addition to clinical parameters to select patients for [Lu]Lu-PSMA-617 radioligand therapy (RLT). Due to increased demand, [Ga]Ga-PSMA-11 was replaced by [F]F-PSMA-1007, a more lipophilic tracer with different biodistribution and splenic uptake was suggested as a new internal reference. We compared the intra-patient tracer distribution between [Ga]Ga-PSMA-11 and [F]F-PSMA-1007.

Can We Predict Skeletal Lesion on Bone Scan Based on Quantitative PSMA PET/CT Features?

Objective: The increasing use of PSMA-PET/CT for restaging prostate cancer (PCa) leads to a patient shift from a non-metastatic situation based on conventional imaging (CI) to a metastatic situation. Since established therapeutic pathways have been designed according to CI, it is unclear how this should be translated to the PSMA-PET/CT results. This study aimed to investigate whether PSMA-PET/CT and clinical parameters could predict the visibility of PSMA-positive lesions on a bone scan (BS).

Imaging of alert patients after non-self-inflicted strangulation: MRI is superior to CT.

Objective: To assess the accuracy of CT and MRI reports of alert patients presenting after non-self-inflicted strangulation (NSIS) and evaluate the appropriateness of these imaging modalities in NSIS.

Material And Methods: The study was a retrospective analysis of patient characteristics and strangulation details, with a comparison of original radiology reports (ORR) to expert read-outs (EXR) of CT and MRI studies of all NSIS cases seen from 2008 to 2020 at a single centre.

Results: The study included 116 patients (71% women, p < .

Evaluation and assessment of clique arrangements for the estimation of omnipolar electrograms in high density electrode arrays: an experimental animal model study.

High-density catheters combined with Orientation Independent Sensing (OIS) methods have emerged as a groundbreaking technology for cardiac substrate characterisation. In this study, we aim to assess the arrangements and constraints to reliably estimate the so-called omnipolar electrogram (oEGM). Performance was evaluated using an experimental animal model.

Magnetic Resonance Imaging in Patients with Cochlear Implants without Magnet Removal: A Radiology-Administered Protocol to Enhance Operational Efficiency and Improve Workflow.

Objective: To describe the development, implementation, and validation of a radiology-administered protocol to obtain magnetic resonance imaging (MRI) in patients with cochlear implants and auditory brainstem implants without magnet removal.

Study Design: Retrospective review and description of novel care pathway.

Methods: A radiology-administered protocol was designed based on careful input from the radiology safety committee and neurotology.

Decomposition and insect succession of pig cadavers in tents versus outdoors - A preliminary study.

The pattern of insect succession and the species composition on cadavers can be influenced by several parameters, one of which is concealment. It has been previously shown for cadavers inside containers (e.g.

MRI Segmentation of Cervical Muscle Volumes in Survived Strangulation: Is There an Association between Side Differences in Muscle Volume and the Handedness of the Perpetrator? A Retrospective Study.

We evaluate the potential value of magnetic resonance imaging (MRI) in the examination of survivors of manual strangulation. Our hypothesis was that trauma-induced edema of the cervical muscles might lead to a side difference in the muscle volumes, associated with the handedness of the perpetrator. In 50 individuals who survived strangulation, we performed MRI-based segmentation of the cervical muscle volumes.

Effects of blood loss on organ attenuation on postmortem CT and organ weight at autopsy.

Background: Cases of external hemorrhage are difficult to recognize on postmortem computed tomography (PMCT).

Purpose: To investigate the effects of blood loss on CT attenuation of the spleen, liver, kidneys, and lungs on PMCT and to assess the relationship between blood loss and organ weight.

Methods: A total of 125 cases with blood loss were sex- and age-matched to 125 control cases without blood loss.

The added value of postmortem magnetic resonance imaging in cases of hanging compared to postmortem computed tomography and autopsy.

The purpose of this study was to evaluate the added value of postmortem magnetic resonance imaging (MRI) compared to postmortem computed tomography (CT) and autopsy in cases of fatal hanging. In addition, the study analyzed the strengths of each examination method regarding typical injuries in these cases. We investigated a cohort of 25 decedents who underwent CT, MRI and autopsy.

Postmortem Magnetic Resonance Imaging and Postmortem Computed Tomography in Ligature and Manual Strangulation.

Purpose: The aim of this study was to evaluate magnetic resonance imaging (MRI) findings in cases of fatal manual or ligature strangulation. Verification of strangulation by computed tomography (CT), MRI, and at autopsy as well as its detectability in each modality was assessed.

Methods: We retrospectively analyzed 6 manual and ligature strangulation cases between 2013 and 2019 who all underwent a whole-body CT, head and neck MRI, and an autopsy.

Comparison of the beta-hydroxybutyrate, glucose, and lactate concentrations derived from postmortem proton magnetic resonance spectroscopy and biochemical analysis for the diagnosis of fatal metabolic disorders.

Purpose: The detection and quantification of metabolites relevant for the diagnosis of fatal metabolic disorders by proton magnetic resonance spectroscopy (1H-MRS) was recently demonstrated. This prospective study aimed to compare the concentrations of beta-hydroxybutyrate (BHB), glucose (GLC), and lactate (LAC) derived from both biochemical analyses and 1H-MRS for the diagnosis of fatal metabolic disorders.

Methods: In total, 20 cases with suspected fatal metabolic disorders were included in the study.

Noninvasive in situ proton MRS in muscle tissue and bone marrow as a novel approach to identify previous freezing in a completely thawed cadaver.

The temporary or permanent storage of human bodies in freezers following a homicide is a documented method for criminal disposal of human corpses. In these cases, the detection of characteristics which indicate that a thawed cadaver or body part was previously frozen provides crucial information for forensic casework. Previous histological and radiological approaches to detect characteristics of previous freezing are based on the formation of bubble-like gas patterns, which are difficult to distinguish from common postmortem gas formation in the course of decomposition.

Rapid death following undiagnosed stercoral perforation in a chronic opioid user.

A case of rapid demise following an undiagnosed stercoral perforation is reported. A 57-year-old woman on chronic opioid replacement therapy presented with constipation and abdominal pain to the hospital. Following an unremarkable abdominal radiograph and admission for laxation and pain therapy, she was found dead only 18 h later.

Noninvasive analysis and identification of an intramuscular fluid collection by postmortem H-MRS in a case of a fatal motor vehicle accident.

In a case of a fatal traffic accident, a suspicious finding was identified in the muscular tissue of the left thigh by whole-body postmortem computed tomography. To better interpret the finding, the lower extremities were investigated by magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (H-MRS). MRI revealed the presence of an evenly distributed intramuscular fluid and H-MRS of a volume within the fluid detected concentrations of acetate and lactate.