USP14 is a predictor of recurrence in endometrial cancer and a molecular target for endometrial cancer treatment.

Endometrial adenocarcinoma is the most common gynecologic malignancy in the United States. Most endometrial cancer cases are diagnosed at an early stage and have good prognosis. Unfortunately a subset of patients with early stage and low grade disease experience recurrence for reasons that remain unclear.

Hepatic failure with neonatal tissue siderosis of hemochromatotic type in an infant presenting with meconium ileus. Case report and differential diagnosis of the perinatal iron storage disorders.

We report on a female preterm infant with hepatic failure and neonatal tissue siderosis of hemochromatotic type diagnosed by using both histochemistry and atomic absorption spectroscopy. The infant presented with meconium ileus, signs of rapidly progressive hepatic failure, and hyperferritinemia (7132 ng/ml). Despite surgery and intensive care the infant died 32 days after birth.

[Reference values of Na(+) and Cl(-) concentrations in adult sweat].

The results of the investigations to reference values for Na(+)- and Cl(-)-concentrations in sweat of adults are as follows: The normal range of electrolyte values in sweat in adults is up to 70 mmol/l (Na+) and 55 mmol/l (Cl-) respectively in infants (40 mmol/l for Na+ and Cl-). There are no sex and age differences. Adults with chronical bronchitis and bronchiectasis don't show different results in comparison with healthy persons.

[Alloxan induced long term diabetes in the domestic pig. I].

An insulin-deficient diabetes of long duration was induced by intravenous injection of alloxanmonohydrate (200 mg/kg and 100 mg/kg body mass, respectively) in 23 pigs (Landrace, Duroc) of 20-44 kg body mass. The dose of 200 mg/kg body mass was too high and there were fatal outcomes only. With the dose of 100 mg/kg and an initial body mass of 30-35 kg it is possible to induce a chronic diabetes mellitus in the pig.

[Peripheral thyroid function and TRH-TSH test in patients with acromegaly].

In 11 patients with acromegaly the peripheral thyroid hormones were determined and a TRH-TSH-test was carried out. Depending on the result of the determination of the growth hormone the patients were classified into two groups (active and inactive acromegaly). The serum thyroxin level and the T3-binding capacity were normal.

[Understanding disorders in the regulatory cycle of the thyroid. Significance for diagnosis and therapy].

In the regulating circle for the regulation of the functions of the thyroid gland interactions exist between hypothalamus, anterior lobe of the pituitary gland, thyroid gland and the concentrations of the thyroid hormone at the periphery. By means of the TRH-test the secretory work of the thyrotropic function of the hypophysis depending on the activity of the thyroid hormone can be judged. On the other hand, the T3-suppression test (radioiodine test before and after application of T3) allows a statement on the hypophyseal-thyroidal regulation.

[Adaptation of lipogenic enzymes of liver and adipose tissue to starvation and refeeding (author's transl)].

The lipogenic enzymes-6-phosphate dehydrogenase, citrate cleavage enzyme and malic enzyme of both liver and adipose tissue of rate of the wistar strain show a diminished activity in dependence on age. In the liver exists no age difference of the characteristic adaptation under the conditions of starvation and refeeding, but in adipose tissue of 18 months old rats the lipogenic enzymes show a poorer elevation of activity during refeeding after a 48 h period of starvation than in 3 months old animals. The serum inulin level and his variation in starvation and refeeding are independent of age.

Insulin secretion in maturity-onset-diabetes. Function of isolated islets.

An impaired insulin response to glucose is a characteristic finding in maturity onset diabetes (MOD). To clarify whether the decreased insulin response in vivo is related to a primary defect of the beta-cells, isolated islets of MOD - obtained by intraoperative biopsy - were examined for their insulin content, biosynthesis and release. The in vitro experiments showed that despite a missing or significantly reduced insulin response in vivo the isolated beta-cells of the same patients had a normal insulin content, a normal or even high biosynthesis, and insulin release could be induced by glucose.

[Endocrine and exocrine functional disorders in pancreatic diabetes].

In diabetic diseases of pancreatic origin we find three typical patterns of insulin secretion. The different insulin secretion allows a clear distinction of a diabetes of the maturity onset type and of the juvenile onset type type on the one hand and of a diabetes caused by a pancreatitis on the other hand. In a pancreatitis we see the expected reduction of the exocrine function.

Diminished insulin response in highly trained athletes.

Insulin secretion and glucose tolerance were examined in 6 highly conditioned athletes in comparison with a control group of 115 normal healthy persons. During glucose infusion the athletes showed low insulin secretion although there was no difference in the levels of blood glucose compared to the control group. It is concluded that under physiologic conditions the extent of insulin secretion is not dependent only upon the blood glucose levels.

[Behavior of the lipid and carbohydrate metabolism in patients with hypertriglyceridemia during exertion].

In pateints with hypertriglyceridaemia in rest and during ergometer load an increased rate of lipolysis with increased metabolism of free fatty acids could be proved. This led to a disturbance of the glucose tolerance with hyperinsulinism and during muscle work to a limitation of the capacity of the oxidative glucose metabolism in musculature.

[Control of therapy for hyperthyroidism. Comparison of in-vitro and in-vivo methods].

55 patients with treated hyperthyroidism (thyreostatics) underwent a T3 suppression test and a TRH stimulation test. 60% of the patients had a positive and 40% a negative T3 suppression test. While patients with a positive T3 suppression test always showed a positive TRH test, the behaviour of the TRH test in negative suppression test was different (68.

[Diagnostic staged program in thyroid diseases].

After some physiological principal remarks the modern possibilities of the in-vitro-diagnostics specific for the thyroid gland are briefly explained. The essential factors of disturbance which are necessary for the avoidance of false interpretations are mentioned. From the sequence of the description (BEJ, T4-test, T3-test, FT4-index, RIA-T3 and RIA-TSH) results the diagnostic step programme proposed by us, by means of which the majority of the functional disturbances of the thyroid gland existing may certainly be classified.