Anthraquinone Residues in Dried Walnut () Leaves for Herbal Infusions: Proof of Endogenous Origin via a Sampling-Driven and GC-MS/MS-Based Strategy.

Anthraquinone residues in tea have been linked to atmospheric deposition. However, anthraquinones can also be biosynthesized in plants. In this work, we report on a sample-driven and GC-MS/MS-based analytical strategy to differentiate between endogenous and exogenous anthraquinones in dried walnut () leaves.

How Inclusive Practice Increases the Educational Relevance of Individualized Education Programs.

Purpose: Individuals with Disabilities Education Act guidelines for Individualized Education Programs (IEPs) require that students with disabilities should, to the fullest extent appropriate, receive services that promote academic achievement that are delivered within the general educational environment. In this clinical focus article, we will demonstrate how the inclusive practice service delivery model can assist speech-language pathologists (SLPs) with the development of educationally relevant IEPs.

Method: Twelve SLPs who saw at least 30% of their students in a general education context shared their perspectives on inclusive practice.

Study on the metabolism of natural sesquiterpene lactones in human liver microsomes using LC-Q-TOF-MS/MS.

Sesquiterpene lactones are naturally occurring, highly active -specialised metabolites, which are biosynthesized by important medicinal plants, fulfilling many functions. The metabolism of parthenolide (), grosheimin (), carbetolide C (), 8-O-(3,4-dihydroxy--methylenebutanoyloxy)-dehydromelitensin () and arteludovicinolide A () was examined using human liver microsomes. Phase , phase (glucuronidation), as well as combined phase + metabolism were studied.

Effect of two additional doses of intrathecal methotrexate during induction therapy on serious infectious toxicity in pediatric patients with acute lymphoblastic leukemia.

Although initial central nervous system (CNS) involvement is rarely detected in childhood acute lymphoblastic leukemia (ALL), risk-adapted CNS-directed therapy is essential for all patients. Treatment intensity depends on the initial CNS status. In the AIEOP-BFM ALL 2009 trial, patients with cytomorphologic detection of leukemic blasts in initial cerebrospinal fluid were classified as CNS2 or CNS3 and received five intrathecal doses of methotrexate (MTX) in induction therapy compared to patients with CNS1 status (no blasts detected) who received three doses.

Terpenoids from Myrrh and Their Cytotoxic Activity against HeLa Cells.

The oleo-gum resin of (Nees) Engl. has a long history of medicinal use, although many of its constituents are still unknown. In the present investigation, 34 secondary metabolites were isolated from myrrh resin using different chromatographic techniques (silica flash chromatography, CPC, and preparative HPLC) and their structures were elucidated with NMR spectroscopy, HRESIMS, CD spectroscopy, and ECD calculations.

Phytochemical Characterization of Phitosia crocifolia, a Monotypic Representative of Greek Flora.

Within the large Compositae family, is considered a monotypic genus of the Greek flora, with its only species (Boiss. & Heldr.) Kamari & Greuter growing wild with limited distribution, exclusively on the mountains Taigetos and Parnonas in Peloponnese.

A Bio-Guided Screening for Antioxidant, Anti-Inflammatory and Hypolipidemic Potential Supported by Non-Targeted Metabolomic Analysis of spp.

This study was designed to evaluate the chemical fingerprints and the antioxidant, anti-inflammatory and hypolipidemic activity of selected species collected in Greece, namely, and (formerly known as ). For the phytochemical analyses, sample measurements were carried out by using nuclear magnetic resonance (NMR) spectroscopy and liquid chromatography coupled with mass spectrometry (LC-MS). Τhe extracts were evaluated both in vitro (radical scavenging activity: DPPH assay and total phenolic content: Folin-Ciocalteu) and in vivo (paw edema reduction and hypolipidemic activity: experimental mouse protocols).

Essential Oils as Multicomponent Mixtures and Their Potential for Human Health and Well-Being.

Essential oils (EOs) and their individual volatile organic constituents have been an inherent part of our civilization for thousands of years. They are widely used as fragrances in perfumes and cosmetics and contribute to a healthy diet, but also act as active ingredients of pharmaceutical products. Their antibacterial, antiviral, and anti-inflammatory properties have qualified EOs early on for both, the causal and symptomatic therapy of a number of diseases, but also for prevention.

Comparing Measures From Computer-Administered and Examiner-Administered Narrative Retells in Spanish: A Pilot Study.

Purpose: Narrative language sample analysis (LSA) is a recommended best practice for the assessment of monolingual and bilingual children. With business-as-usual narrative LSA, examiners are actively involved in all aspects of the elicitation. Software advancements have shown multiple benefits of computer-administered language assessments, some of which may be beneficial for narrative assessments, particularly for bilingual children.

An organophotocatalytic late-stage N-CH oxidation of trialkylamines to -formamides with O in continuous flow.

We report an organophotocatalytic, N-CH-selective oxidation of trialkylamines in continuous flow. Based on the 9,10-dicyanoanthracene (DCA) core, a new catalyst (DCAS) was designed with solubilizing groups for flow processing. This allowed O to be harnessed as a sustainable oxidant for late-stage photocatalytic N-CH oxidations of complex natural products and active pharmaceutical ingredients bearing functional groups not tolerated by previous methods.

Soil and Vegetation Drive Sesquiterpene Lactone Content and Profile in L. Flower Heads From Apuseni-Mountains, Romania.

L. (, Asteraceae) is a perennial, herbaceous vascular plant species of commercial importance. The flower heads' pharmacological properties are attributed mainly to sesquiterpene lactones (SLs), with phenolic acids and flavonoids also considered of relevance.

Dynamic Norming for Systematic Analysis of Language Transcripts.

Purpose: This exploratory study sought to establish the psychometric stability of a dynamic norming system using the Systematic Analysis of Language Transcripts (SALT) databases. Dynamic norming is the process by which clinicians select a subset of the normative database sample matched to their individual client's demographic characteristics.

Method: The English Conversation and Student-Selected Story (SSS) Narrative databases from SALT were used to conduct the analyses in two phases.

In Vitro Liver Metabolism of Six Flavonoid C-Glycosides.

Several medical plants belonging to the genera , , and accumulate flavonoid C-glycosides, which likely contribute to their efficacy. Information regarding their phase I and II metabolism in the liver are lacking. Thus, in vitro liver metabolism of orientin, isoorientin, schaftoside, isoschaftoside, vitexin, and isovitexin, all of which accumulated in L.

Macrocyclic Diterpenoid Constituents of , an Endemic Spurge from Greece.

, an endemic spurge from Greece, was investigated for the occurrence of its diterpene constituents. Through continuous monitoring by H NMR, 22 diterpenoids were isolated, including 16 previously undescribed compounds (euphodeflexins A-P), which belong to the jatrophane, ingenane, segetane, and pepluane diterpene types. Their chemical structures were elucidated through a combination of HRESIMS, NMR spectroscopy, and X-ray data.

Homoadamantane and Adamantane Acylphloroglucinols from Hypericum hirsutum.

H NMR-guided fractionation of the petroleum ether extract of the aerial parts from yielded to the isolation of 19 polyprenylated polycyclic acylphloroglucinols. Structure elucidation based on 1D and 2D NMR spectroscopy together with high-resolution electrospray ionization mass spectroscopy revealed 14 acylphloroglucinols with a homoadamantane scaffold (1: -14: ), while 5 further compounds showed an adamantane skeleton (15: -19: ). Except for hookerione C (15: ), all isolated metabolites are hitherto unknown.

Cajamolides A-N: Cytotoxic and anti-inflammatory sesquiterpene lactones from Calea jamaicensis.

In the search for bioactive compounds from natural sources against cancer and inflammation, Calea jamaicensis (L.) L., a plant endemic to Panama, was investigated.

Identification of Gaps in Training, Research, and School-Based Practice: A Survey of School-Based Speech-Language Pathologists.

Purpose Speech-language pathologists (SLPs) encounter many challenges in the school environment. We sought to identify school-based SLPs' needs in the areas of training and research to support school-based practice. Method We collected surveys from 145 school-based SLPs practicing in Wisconsin.

Prenylated Acylphloroglucinols from Hypericum jovis with Anti-inflammatory Potential.

Thirteen prenylated acylphloroglucinols (1: -13: ), including 2 previously undescribed compounds (1: ) and (2: ), were isolated from Their structures were elucidated by high-field NMR spectroscopy. The isolated prenylated acylphloroglucinols were evaluated for their anti-inflammatory effects through the reduction of the intercellular adhesion molecule 1 expression induced by TNF- in the human microvascular endothelial cells 1 cell line. Compounds 3, 5, 6, 8,: and 12: significantly reduced intercellular adhesion molecule 1 expression in a concentration-dependent manner with IC values of 16.

cytotoxic and anti-inflammatory activities of sesquiterpene lactones from (Coss.) Greuter.

In the pursuit of highly active specialized metabolites from endemic plants, (Coss.) Greuter, an endemic plant in Algeria and Tunisia, was investigated and afforded eleven sesquiterpene lactones (-). Cytotoxic evaluation of these compounds using the MTT assay on three human cancerous cell lines (HeLa, SK-MEL-28 and HepG2), revealed that isolates , and (IC ≤ 10 μM) could be potential anti-cancer drugs for cervical cancer according to the National Cancer Institute.

In Vitro Metabolism of Six C-Glycosidic Flavonoids from L.

Several medical plants, such as L., contain C-glycosylated flavonoids, which may contribute to their efficacy. Information regarding the bioavailability and metabolism of these compounds is essential, but not sufficiently available.