Publications by authors named "Heiko Himpfen"
Article Synopsis
- White matter hyperintensities (WMH) are common in older adults' brain scans and are influenced by vascular risks like hypertension, which are linked to cognitive impairments.
- A study involving 560 participants revealed that WMH mainly affects the frontal lobe, followed by the parietal, temporal, and occipital lobes, and higher WMH scores correlate with increased blood pressure and antihypertensive treatments.
- Higher WMH scores in the frontal and parietal lobes are associated with poorer performance in executive functions and memory, highlighting the cognitive impact of hypertension-related WMH.
Objectives: White matter hyperintensities (WMH) of presumed vascular origin are frequent in cerebral MRI of older people. They represent a sign of small vessel disease, are promoted by arterial hypertension, and relate to cognitive deficits. The interdependence of blood pressure and its treatment, WMH, and cognitive performance has not systematically been studied in population-based studies.
View Article and Find Full Text PDFBackground And Purpose: Cross-sectional studies showed an inverse association between serum 25-hydroxyvitamin D (25OHD) and white matter hyperintensities (WMHs) whereas the few longitudinal studies did not. The association between baseline 25OHD and WMHs at 10-year follow-up in the Heinz Nixdorf Recall Study plus 1000BRAINS was investigated.
Methods: Data of 505 participants (49% women, 56.