Publications by authors named "Heike Streitenberger"
Ten percent of children with cancer harbour a mutation in a predisposition gene. In children with the kidney cancer, Wilms tumour, the prevalence is as high as 30%. Certain predispositions are associated with defined histological and clinical features, suggesting differences in tumourigenesis.
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- - The study focuses on congenital mesoblastic nephroma (CMN) and its genetic characteristics, comparing it with related soft tissue tumors of infancy.
- - A significant discovery includes a recurrent mutation in the EGFR gene specific to CMN, helping to differentiate it from other pediatric kidney tumors.
- - The research also identifies intragenic rearrangements in the BRAF gene in both CMN and infantile fibrosarcoma (IFS), suggesting new diagnostic markers and potential treatments for these tumors.