Publications by authors named "Heike Sartor"
Background: Screening of unvaccinated women remains essential to mitigate the high morbidity/mortality of cervical cancer. Here, we compared visual inspection with acetic acid (VIA), recommended by WHO as the most cost-effective screening approach in LMICs, with HPV-based screening, and usage of p16/Ki-67 dual stain cytology.
Methods: We prospectively enrolled women participating in a VIA-based cervical cancer screening program in two peri-urban health centers of Kenya.
Article Synopsis
- A study in rural Ethiopia showed that using HPV testing combined with local medical exams is a good way to screen for cervical cancer in women aged 25-65.
- In the campaign, 85% of the women agreed to be screened, and 57% had samples that were suitable for testing.
- The results indicated that this self-sampling and testing method could work well in communities with fewer resources, especially if there are strong community programs and technology in place.
Diffuse overexpression of p16(INK4a) in basal and parabasal cells of cervical epithelium is a hallmark of human papillomavirus-mediated transformation. Focal p16(INK4a) expression is occasionally observed in nondysplastic epithelium. In normal cells, expression of p16(INK4a) triggers cell cycle arrest.
View Article and Find Full Text PDFBackground: Dysplastic lesions of the vagina or the vulva often occur in women who have a previous history of cervical dysplasia. Most lesions in the female lower genital tract are induced by infections with high-risk oncogenic human papillomaviruses (HR-HPVs), including HPV16 and HPV18. HR-HPV genomes frequently integrate into host cell chromosomes at random sites.
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