Publications by authors named "Heike Rau"
Article Synopsis
- SSIs are common after abdominal surgery, affecting about 20% of patients and increasing mortality by 12%, highlighting the need for effective prevention strategies like antibiotic prophylaxis.
- The RESISTAAS I study will observe 300 patients undergoing major abdominal surgery to evaluate the practice of antibiotic redosing and its impact on postoperative SSIs and other related outcomes.
- Conducted under strict ethical guidelines, the study is approved by the Medical Ethics Review Board of Heidelberg University and aims to share findings in a peer-reviewed journal.
Dalbavancin is emerging as a promising alternative in the ambulant treatment of gram-positive infections that require long-term antibiotic treatment such as osteomyelitis, prosthetic joint infections, and endocarditis. The aim of the current study was to develop and validate a simple, rapid, and cost-effective high-performance liquid chromatography-ultraviolet spectrometry (HPLC-UV) method for the quantification of dalbavancin. Sample clean-up included a protein precipitation protocol, followed by chromatographic separation on a reverse phase HPLC column (C-18) with gradient elution of the mobile phase.
View Article and Find Full Text PDFPurpose: In critically ill patients, changes in the pharmacokinetics (PK) of β-lactams can lead to significant variations in serum concentrations, with possibly detrimental effects on outcomes. The utilization of individually calculated doses, extended infusion regimen, and therapeutic drug monitoring (TDM)-guided dose adjustments can mitigate the PK changes and help to achieve and attain an individual PK target.
Methods: We reviewed relevant literature from 2004 to 2021 using 4 search engines (PubMed, Web of Science, Scopus, and Google Scholar).