Control of mitogenic and motogenic pathways by miR-198, diminishing hepatoma cell growth and migration.

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer deaths, worldwide. MicroRNAs, inhibiting gene expression by targeting various transcripts, are involved in genomic dysregulation during hepatocellular tumorigenesis. In previous studies, microRNA-198 (miR-198) was shown to be significantly downregulated in HCV-positive hepatocellular carcinoma (HCC).

Telmisartan plus propranolol improves liver fibrosis and bile duct proliferation in the PSC-like Abcb4-/- mouse model.

Background: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease leading to cirrhosis and cholangiocellular carcinoma. Inhibitors of the renin-angiotensin system or the sympathetic nervous system delay liver fibrogenesis in animal models.

Aims: We investigated the antifibrotic potential of telmisartan, an angiotensin II type 1 receptor antagonist, and the β-adrenoceptor blocker propranolol in the PSC-like Abcb4 knockout mouse model.

Practical issues for frozen section diagnosis in gastrointestinal and liver diseases.

Surgeons frequently utilize frozen sections as a tool to gain information intraoperatively. The use of frozen sections has certain benefits as well as limitations which vary according to the situation. After reviewing the available literature we provide the reader with an idea of when and how to use frozen sections in common situations involving the gastrointestinal tract and liver as well as address the benefits and limitations in each setting.