Low dose isotretinoin combined with tretinoin is effective to correct abnormalities of acne.

Background: Isotretinoin is well known in the therapy of acne papulopustulosa and acne conglobata. No study has investigated the pathophysiological changes of the skin of acne patients, especially when low dose oral isotretinoin is given in combination with topical tretinoin.

Patients And Methods: 28 patients were treated for 6 months with oral isotretinoin.