Avoidance of excessively deep sedation levels is problematic in intensive care patients. Electrophysiologic monitoring may offer an approach to solving this problem. Since electroencephalogram (EEG) responses to different sedation regimens vary, we assessed electrophysiologic responses to two sedative drug regimens in 10 healthy volunteers.
View Article and Find Full Text PDFObjective: The aim of our study was to examine the role of brain activity related to stimulus evaluation processes in distractibility by analyzing the P3 event-related potential.
Methods: We studied the P3 response to target stimuli at the beginning, in the middle, and at the end of a two-tone auditory oddball task in easily distractible (n = 16) and non-distractible (n = 16) adolescents.
Results: Easily distractible adolescents showed enhanced frontal and reduced parietal P3 amplitude across the blocks relative to non-distractible adolescents.
J Cardiothorac Vasc Anesth
October 2004
Objectives: Midlatency auditory-evoked potentials (MLAEPs) may provide an objective measure of depth of sedation. The aim of this study was to evaluate MLAEPs for measuring sedation in cardiac surgery patients.
Design: Prospective study.
Introduction: In this observational pilot study we evaluated the electroencephalogram (EEG) and auditory event-related potentials (ERPs) before and after discontinuation of propofol sedation in neurologically intact intensive care patients.
Methods: Nineteen intensive care unit patients received a propofol infusion in accordance with a sedation protocol. The EEG signal and the ERPs were measured at the frontal region (Fz) and central region (Cz), both during propofol sedation and after cessation of infusion when the sedative effects had subsided.
Objective: In the present study, we evaluated the electroencephalogram (EEG) and auditory N100 potential (N100) before and during propofol-induced sedation. The aim was to test whether using EEG and N100 the level of sedation may be evaluated.
Methods: Twenty-nine cardiac surgery patients were studied.
Avoiding excessively deep levels of sedation is a major problem in intensive care patients. We studied whether clinically relevant levels of sedation can be objectively assessed using long latency auditory evoked potentials. We measured the auditory evoked potentials at 100 ms after the stimulus (N100) in 10 healthy volunteers during stepwise increasing, clinically relevant levels of sedation (Ramsay score [RS] 2-4).
View Article and Find Full Text PDFObjectives: Several sedation scores have been developed, but still a need exists for an objective method to monitor sedation level during intensive care. Our study presents a procedure for finding a combination of electroencephalogram (EEG) characteristics, which could be used in estimating sedation level.
Methods: We measured EEG in 29 cardiac surgical patients prior to and after the cardiac bypass grafting operation at different sedation levels.
Objectives: Our aim was to characterize cerebral event-related responses, which index the detection of auditory stimuli during postoperative sedation.
Methods: We monitored auditory event-related potentials (ERPs) before and after elective cardiac operation in 29 patients. Sedation levels, induced with propofol, were evaluated clinically with Ramsay score (RS).
In psychosis, behavior is not guided by sensory cues from surroundings. Novel, meaningful behaviors require intact integrative functions such as short-term memory and motor planning, as well as an optimized level of arousal. In this study, we monitored markers of automatic auditory processing in 15 female never-medicated psychotic patients.
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