Publications by authors named "Heidi Schaarschmidt"
Atopic dermatitis is a common inflammatory skin disease with a strong heritable component. Pathogenetic models consider keratinocyte differentiation defects and immune alterations as scaffolds, and recent data indicate a role for autoreactivity in at least a subgroup of patients. FLG (encoding filaggrin) has been identified as a major locus causing skin barrier deficiency.
View Article and Find Full Text PDFBackground: Atopic dermatitis (AD) is a common inflammatory skin disease. Previous studies have revealed shared genetic determinants among different inflammatory disorders, suggesting that markers associated with immune-related traits might also play a role in AD.
Objective: We sought to identify novel genetic risk factors for AD.
Article Synopsis
- Atopic dermatitis is a long-lasting inflammatory skin condition influenced by both genetics and the environment.
- A study involved a genome-wide analysis of atopic dermatitis in a large Chinese Han population and included additional samples from Germany, leading to the identification of new genetic markers associated with the condition.
- The findings reveal new potential genetic factors that contribute to atopic dermatitis and suggest new biological pathways that could be explored for better understanding and treatment.