Re: Aducanumab-Related ARIA: Paean or Lament?

Høilund-Carlsen and colleagues raise concern regarding the reliability of amyloid PET to exclude Alzheimer disease. We present additional studies of amyloid PET and discuss the diagnostic challenges in Alzheimer disease. We discuss the limitations of amyloid in diagnosis and evaluation of therapy response in AD.

Commentary: Aducanumab-Related ARIA: Paean or Lament?

Høilund-Carlsen and colleagues raise important issues related to amyloid PET, diagnosis of Alzheimer disease, and recently approved antiamyloid treatment aducanumab. We discuss new developments that may direct us to methods of presymptomatic detection of Alzheimer disease and development of effective prevention and therapy.

FDG PET/CT in Mixed Langerhans Cell Histiocytosis and Erdheim-Chester Disease.

The histiocytoses arise from hematopoietic bone marrow stem cells or monocytes. They range from limited to disseminated disease. We report a 31-year-old woman with multisystem Langerhans cell histiocytosis (LCH).

Nuclear Medicine Student Elective at the Keck School of Medicine at LAC-USC Medical Center.

Very few medical schools offer a nuclear medicine elective. I will share our experience with the nuclear medicine elective rotation which has been well received by our fourth-year medical students. This may be of interest to nuclear medicine physicians who work in an academic setting.

Musculoskeletal Pitfalls on Fluorodeoxyglucose F 18 PET-Computed Tomography: Pictorial Review.

A wide range of musculoskeletal processes can demonstrate increased uptake on PET-computed tomography (CT) with fluorodeoxyglucose (FDG) F 18, including reactive, benign neoplastic, inflammatory, traumatic, posttreatment, and arthritic conditions that may mimic malignancy. In addition, physiologic causes of increased FDG uptake such as asymmetric muscle use and presence of brown fat can lead to increased FDG uptake and potential false-positive results. This article presents various case examples of non-malignant musculoskeletal hypermetabolism on 18F-FDG PET-CT and describes useful tools to avoid the potential pitfall of misinterpreting these as malignancy.

Nuclear Medicine Imaging in the Dentomaxillofacial Region.

Nuclear medicine studies evaluate physiology on a molecular level providing earlier detection of lesions before morphologic change is evident. Tc-MDP and F-fluoride bone scans detect osteomyelitis earlier than radiographs and computed tomography (CT); aid in diagnosis of temporomandibular joint disorder; and evaluate activity of condylar hyperplasia, extent of Paget disease, and viability of bone grafts. F-FDG PET/CT distinguish between soft tissue and bone infections and diagnose osteomyelitis complicated by fracture or surgery.

PET/CT in Head-neck Malignancies: The Implications for Personalized Clinical Practice.

PET/CT has been shown to help localize head and neck cancers and provide more accurate staging, post-treatment assessment, and restaging than standard imaging. PET/CT detects synchronous and metachronous cancers and sequelae of therapy and provides prognostic information for each patient. Information provided by PET/CT allows for more individualized therapeutic and surveillance plans for patients with head and neck squamous cell carcinoma.