HIV-Specific CD8 T Cells Exhibit Reduced and Differentially Regulated Cytolytic Activity in Lymphoid Tissue.

Elimination of lymphoid tissue reservoirs is a key component of HIV eradication strategies. CD8 T cells play a critical role in control of HIV, but their functional attributes in lymph nodes (LNs) remain unclear. Here, we show that memory, follicular CXCR5, and HIV-specific CD8 T cells from LNs do not manifest the properties of cytolytic CD8 T cells.