Safety and efficacy of MIM-D3 ophthalmic solutions in a randomized, placebo-controlled Phase 2 clinical trial in patients with dry eye.

Purpose: To evaluate the safety and efficacy of ophthalmic MIM-D3, a tyrosine kinase TrkA receptor agonist, in patients with dry eye.

Design: A prospective, two-center, randomized, double-masked, placebo-controlled Phase 2 study.

Methods: A total of 150 dry eye patients were randomized 1:1:1 to study medication (1% MIM-D3, 5% MIM-D3, or placebo) and dosed twice daily (BID) for 28 days.

A randomized trial of the efficacy of hand disinfection for prevention of rhinovirus infection.

Background: Hand disinfection is frequently recommended for prevention of rhinovirus (RV) infection and RV-associated common colds. The effectiveness of this intervention has not been established in a natural setting. The purpose of this study was to determine the effect of hand disinfection on RV infection and RV-associated common cold illness in a natural setting.

Effect of varying dispenser point source density on mating disruption of Grapholita molesta (Lepidoptera: Tortricidae).

Hand-applied dispensers are successfully used in mating disruption programs, but cost of labor to apply these dispensers limits their adoption. Creating hand-applied dispensers that release larger amounts of pheromone and that can be applied at lower densities per hectare could reduce the cost of mating disruption and increase its use. The effect of reducing the number of point sources per hectare while keeping the amount of pheromone applied per hectare constant on the success of Grapholita molesta (Busck) (Lepidoptera: Tortricidae) mating disruption was investigated with Confuse-OFM, paraffin disk, and Isomate-M Rosso dispensers.