Cross-section of thyroidology and nephrology: Literature review and key points for clinicians.

There are several key points clinicians should consider when managing patients with overlapping thyroid and renal disease. Patients who are euthyroid and have chronic kidney disease (CKD) may physiologically have normal-high thyroid stimulating hormone (TSH), low free thyroxine (FT4), low free triiodothyronine (FT3) and normal-low reverse triiodothyronine (rT3). Untreated subclinical and primary hypothyroidism among patients with (CKD) is associated with reversible progression of renal failure.

In T2DM uncontrolled with noninsulin glucose-lowering agents, weekly icodec reduced HbA vs. daily glargine at 52 wk.

Rosenstock J, Bain SC, Gowda A, et al; ONWARDS 1 Trial Investigators. N Engl J Med. 2023;389:297-308.

In T2DM uncontrolled with noninsulin glucose-lowering agents, weekly icodec reduced HbA vs. daily degludec at 26 wk.

Lingvay I, Asong M, Desouza C, et al. JAMA. 2023;330:228-237.

In uncontrolled T2DM treated with a basal-bolus insulin regimen, weekly icodec was noninferior to daily glargine for HbA at 26 wk.

Mathieu C, Ásbjörnsdóttir B, Bajaj HS, et al. Lancet. 2023;401:1929-1940.