Publications by authors named "Heh-Shiang Sheu"
Article Synopsis
- Thiopurine methyltransferase (TPMT) is crucial in metabolizing Azathioprine (AZA), and variations in TPMT genes may lead to different side effects like myelosuppression and hepatotoxicity.
- This study focused on the link between TPMT gene variations and hepatotoxicity in Asian patients who had previously used AZA, involving a total of 50 non-normal metabolizer (non-NM) patients and 1000 normal metabolizers (NM).
- Results indicated that non-NM patients had a significantly higher risk of hepatotoxicity, with cumulative incidence rates rising over three years, suggesting that genetic testing for TPMT variants can help tailor safer AZA treatments.
