Publications by authors named "Hefa Mangzira Kemung"
Article Synopsis
- There is a growing need for new antibiotics due to antibiotic-resistant bacteria like MRSA, and researchers discovered a new strain, MUSC 125, from mangrove soil in Malaysia that shows promise against this issue.
- The methanolic extract from strain MUSC 125 exhibited anti-MRSA, anti-biofilm, and antioxidant properties, and contained specific polyketide synthase gene clusters suggested to be linked to these effects.
- Chemical analysis identified eight compounds in the extract that could contribute to its antibiotic activity, indicating that strain MUSC 125 may be a valuable resource for developing new anti-MRSA treatments.
Article Synopsis
- The mangrove ecosystem in Malaysia is still being explored for microbes that can produce beneficial metabolites, particularly focusing on strain MUSC 14 from Pahang.
- Strain MUSC 14 has been identified based on its genetic and physical traits, and it exhibits strong antioxidant properties when tested against various assays.
- The study highlights a significant link between the strain's phenolic content and its antioxidant activity, suggesting potential for therapeutic applications of its metabolites.
Methicillin-resistant (MRSA) pose a significant health threat as they tend to cause severe infections in vulnerable populations and are difficult to treat due to a limited range of effective antibiotics and also their ability to form biofilm. These organisms were once limited to hospital acquired infections but are now widely present in the community and even in animals. Furthermore, these organisms are constantly evolving to develop resistance to more antibiotics.
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