a neuropeptide receptor, regulates organismal lifespan and stress tolerance in .

The mechanisms underlying neuropeptide signaling regulation of lifespan in ( ) remain unclear. FRPR-18 is a mammalian orexin/hypocretin-like receptor and modulates arousal behavior by acting as a receptor for FLP-2 neuropeptide signaling, which is also associated with the systemic activation of the mitochondrial unfolded protein response (mitoUPR). Here we report our preliminary findings on the role of the gene in regulating lifespan and healthspan parameters, including stress resistance.