Publications by authors named "Heetanshi Jain"
Article Synopsis
- Gut microbiome dysbiosis contributes to various health issues, and the study explores the role of bacterial extracellular vesicles (bEVs) in communication between gut microbiota and other organs.
- The research developed a method to isolate LPS+ bEVs from various biological samples and used multiple techniques to characterize them, particularly focusing on their effect on liver tissues in diet-induced obese (DIO) mice.
- Findings showed that DIO mice had lower total bEVs but higher LPS+ bEVs, with increased immune-related gene expressions in liver, indicating that bEVs might play a crucial role in the influence of gut bacteria on other body systems.
Ischemic stroke is the second leading cause of death and disability worldwide, and efforts to prevent stroke, mitigate secondary neurological damage, and promote neurological recovery remain paramount. Recent findings highlight the critical importance of microbiome-related metabolites, including vitamin B12 (VB12), in alleviating toxic stroke-associated neuroinflammation. Here, we showed that VB12 tonically programmed genes supporting microglial cell division and activation and critically controlled cellular fatty acid metabolism in homeostasis.
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- * Researchers are exploring extracellular vesicles (EVs) as promising biomarkers for various conditions, which can provide crucial information about hard-to-reach tissues in a less invasive way, akin to "liquid biopsies".
- * This study identified specific proteins in small EVs from the adipose tissue of lean and obese mice, suggesting that these EVs can help predict disease and indicate significant changes related to inflammation and amino acid metabolism associated with obesity.