Cytoplasmic WEE1 promotes resistance to PD-1 blockade through hyperactivation of the HSP90A/TCL1/AKT signaling axis in NANOGhigh tumors.

Immune checkpoint blockade (ICB) has revolutionized the therapeutic landscape across various cancer types. However, the emergence of resistance to ICB therapy limits its clinical application. Therefore, it is necessary to better understand immune-resistance mechanisms that could be targeted by actionable drugs, and important to identify predictive markers for selecting patients.

Effects of Alcohol Consumption Frequency on Health Index in Korean Women.

Background: In this study, we examined the status of Korean women's alcohol consumption and identified the physical changes they undergo according to the level of consumption. The results of this study may thus be used as raw data to effectively control women' drinking habits.

Methods: This study consists of a secondary analysis using data from female participants in the 6 Korea National Health and Nutrition Examination Survey, which was conducted by the Korea Centers for Disease Control and Prevention(2013-2014, V-2).