Orange maker: a CRISPR/Cas9-mediated genome editing and screening project to generate orange-eyed DarkJedi GAL4 lines by undergraduate students.

One of the greatest strengths of Drosophila genetics is its easily observable and selectable phenotypic markers. The mini-white marker has been widely used as a transgenic marker for Drosophila transgenesis. Flies carrying a mini-white construct can exhibit various eye colors ranging from pale orange to intense red, depending on the insertion site and gene dosage.

The Scope of Practice of an Embedded Pediatric Palliative Oncology Clinic.

Context: Pediatric palliative care (PPC) improves end-of-life (EOL) outcomes for children with cancer. Though PPC visits are the 'intervention' in studies focused on EOL care, the content of PPC visits within pediatric oncology is poorly understood.

Objectives: This study aimed to understand the scope of PPC practice during visits for children with cancer and their families.

Association of Severe Acute Respiratory Syndrome Coronavirus 2 Infection With Early Breastfeeding.

Objective: The association of maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) status before delivery with breastfeeding is unknown. This study compares breastfeeding initiation, exclusivity, and duration between SARS-CoV-2-positive (+) and SARS-CoV-2-negative (-) mothers during the first 2 months of their newborns' lives.

Methods: A single center, retrospective cohort study of pediatric contacts during the first 2 months in a diverse mother-infant population (n = 285) compared breastfeeding outcomes by maternal SARS-CoV-2 status during a pandemic surge.

Quantum State Learning via Single-Shot Measurements.

A novel machine-learning algorithm based on single-shot measurements, named single-shot measurement learning, is demonstrated achieving the theoretical optimal accuracy. The method is at least as efficient as existing tomographic schemes and computationally much less demanding. The merits are attributed to the inclusion of weighted randomness in the learning rule governing the exploration of diverse learning routes.

Vaccine Development: From Laboratory to Policy.

Vaccines are one of the greatest public health achievements, protecting children and adults against numerous infectious diseases; however, the complex, rigorous process of vaccine development is unknown to many. A candidate vaccine undergoes extensive evaluation of safety and efficacy to meet licensure requirements before recommendations for use become policy. This time-consuming process involves an intricate collaboration among academia, public and private organizations, and federal agencies to ensure that safety is prioritized in every step.

Deterministic Secure Quantum Communication on the BB84 System.

In this paper, we propose a deterministic secure quantum communication (DSQC) protocol based on the BB84 system. We developed this protocol to include quantum entity authentication in the DSQC procedure. By first performing quantum entity authentication, it was possible to prevent third-party intervention.

Quantum Teleportation of Shared Quantum Secret.

Quantum teleportation is a fundamental building block of quantum communications and quantum computations, transferring quantum states between distant physical entities. In the context of quantum secret sharing, the teleportation of quantum information shared by multiple parties without concentrating the information at any place is essential, and this cannot be realized by any previous scheme. We propose and experimentally demonstrate a novel teleportation protocol that enables one to perform this task.

Measurement of bending-induced birefringence in a hollow-core photonic crystal fiber.

We report the measurement of bending-induced birefringence in the presence of large intrinsic birefringence in a hollow-core photonic crystal fiber (HC-PCF). The fast axis of bending-induced birefringence was found to be normal to the bending plane, in contrast to the conventional fiber case. The dependence of the induced birefringence on the bending radius was also different from the typical inverse square law.

Relative time multiplexing of heralded telecom-band single-photon sources using switchable optical fiber delays.

We experimentally demonstrate a time-multiplexing method for pulse-pumped heralded single-photon sources using switchable optical fiber delay lines. The optical fibers constitute a 32-channel binary-division photon buffer that can multiplex time slots into single temporal mode to enhance single-photon generation rate without increasing multi-photon noise. Relative time multiplexing using the same actively controlled variable delay realizes Hong-Ou-Mandel interferometry by two photons produced in arbitrary two time-bins.

Urinary neutrophil gelatinase-associated lipocalin as a biomarker of acute kidney injury in sepsis patients in the emergency department.

Background: Plasma neutrophil gelatinase-associated lipocalin (NGAL) is a useful biomarker for predicting acute kidney injury (AKI). The purpose of this study was to evaluate the diagnostic performance of urinary NGAL in predicting AKI in sepsis patients in the emergency department.

Methods: A total of 140 patients were enrolled.

Targeting High Mobility Group Box-1 (HMGB1) Promotes Cell Death in Myelodysplastic Syndrome.

Purpose: Myelodysplastic syndrome (MDS) is associated with a dysregulated innate immune system. The purpose of this study was to determine whether modulation of the innate immune system via high mobility group box-1 (HMGB1) could reduce cell viability in MDS.

Experimental Design: We quantified HMGB1 in an MDS cell line MDS-L and in primary MDS cells compared with nonmalignant hematopoietic cells.

Effect of effortful swallowing training on tongue strength and oropharyngeal swallowing function in stroke patients with dysphagia: a double-blind, randomized controlled trial.

Background: Effortful swallowing training (EST) is a remedial method for the training of swallowing-related muscles in the oropharyngeal phase. However, clinical evidence of its effectiveness is insufficient.

Aims: To investigate the effects of EST on tongue strength and swallowing function in patients with stroke.

Efficient High-Dimensional Quantum Key Distribution with Hybrid Encoding.

We propose a schematic setup of quantum key distribution (QKD) with an improved secret key rate based on high-dimensional quantum states. Two degrees-of-freedom of a single photon, orbital angular momentum modes, and multi-path modes, are used to encode secret key information. Its practical implementation consists of optical elements that are within the reach of current technologies such as a multiport interferometer.

Comparison of orbicularis oris muscle strength and endurance in young and elderly adults.

[Purpose] The purpose of this study was to compare the strength and endurance of the orbicularis oris muscle in healthy Korean (young vs. elderly adults). [Participants and Methods] A total of 60 participants (30 young adults and 30 elderly adults) were recruited.

Effect of orbicularis oris muscle training on muscle strength and lip closure function in patients with stroke and swallowing disorder.

[Purpose] We aimed to investigate the effect of resistance training of the orbicularis oris muscles on lip muscle strength and closure function in patients with swallowing disorder with facial palsy after stroke. [Participants and Methods] This study recruited 10 patients with swallowing disorder and facial palsy after stroke. All the participants received orbicularis oris muscle training at an intensity of 70% of 1 repetition maximum by using an Iowa oral performance instrument.

Effect of mirror therapy and electrical stimulation on upper extremity function in stroke with hemiplegic patient: a pilot study.

[Purpose] This study investigated the effects of mirror therapy and neuromuscular electrical stimulation on upper extremity function in stroke patients. [Subjects and Methods] This study recruited 8 stroke patients. All patients were treated with mirror therapy and neuromuscular electrical stimulation five times per week for 4 weeks.

Experimental Demonstration of Four-Dimensional Photonic Spatial Entanglement between Multi-core Optical Fibres.

Fibre transport of multi-dimensional photonic quantum states promises high information capacity per photon without space restriction. This work experimentally demonstrates transmission of spatial ququarts through multi-core optical fibres and measurement of the entanglement between two fibres with quantum state analyzers, each composed of a spatial light modulator and a single-mode fibre. Quantum state tomography reconstructs the four-dimension entangled state that verifies the nonlocality through concurrences in two-dimensional subspaces, a lower bound of four-dimensional concurrence and a Bell-type CGLMP inequality.

Primary Thyroid Angiosarcoma with Tracheal Invasion.

A 48-year-old woman was referred to our clinic because she had been experiencing hemoptysis for 1 month. Chest computed tomography revealed a small portion of a thyroid mass was penetrating the trachea. Bronchoscopy revealed a blood vessel covered mass located in her trachea.

Multi-core fiber interferometer using spatial light modulators for measurement of the inter-core group index differences.

We demonstrate an experimental technique to generate and measure arbitrary superpositions of core modes in a multi-core fiber. Two spatial light modulators couple the fundamental mode of a single-mode fiber with multiple-core modes of the MCF to constitute a Mach-Zehnder-type multi-path interferometer. The phase tunability of each path is verified by comparing two-, three-, and four-path interference patterns with the theory.

Acousto-optic resonant coupling of three spatial modes in an optical fiber.

A fiber-optic analogue to an externally driven three-level quantum state is demonstrated by acousto-optic coupling of the spatial modes in a few-mode fiber. Under the condition analogous to electromagnetically induced transparency, a narrow-bandwidth transmission within an absorption band for the fundamental mode is demonstrated. The presented structure is an efficient converter between the fundamental mode and the higher-order modes that cannot be easily addressed by previous techniques, therefore can play a significant role in the next-generation space-division multiplexing communications as an arbitrarily mode-selectable router.

Experimental direct estimation of nonlinear functionals of photonic quantum states via interferometry with a controlled-swap operation.

We propose a multi-photon interferometer with a generalized C-SWAP operation that can estimate Tr[ρ(1)ρ(2)···ρ(n)], a nonlinear functional of n photonic density matrices. The scheme is demonstrated for three single-photon states whose overlap is experimentally measured as the interference visibility of a control qubit encoded into photonic paths. The validity of this method is verified by comparing the visibility with the results of Hong-Ou-Mandel experiments.

Measurement of the entanglement between photonic spatial modes in optical fibers.

We experimentally demonstrate the entanglement of spatial modes between two photons propagating through separate few-mode optical fibers. Quantum states over the two lowest-order spatial modes are measured with highly efficient spatial-mode analyzers based on acousto-optics. Quantum state tomography verifies the entanglement of the spatial-domain Bell state.

Experimental realization of a four-photon seven-qubit graph state for one-way quantum computation.

We propose and demonstrate the scaling up of photonic graph states through path qubit fusion. Two path qubits from separate two-photon four-qubit states are fused to generate a two-dimensional seven-qubit graph state composed of polarization and path qubits. Genuine seven-qubit entanglement is verified by evaluating the witness operator.

Observation of Young's double-slit interference with the three-photon N00N state.

Spatial interference of quantum mechanical particles exhibits a fundamental feature of quantum mechanics. A two-mode entangled state of N particles known as N00N state can give rise to non-classical interference. We report the first experimental observation of a three-photon N00N state exhibiting Young's double-slit type spatial quantum interference.

Three-photon N00N states generated by photon subtraction from double photon pairs.

We describe an experimental demonstration of a novel three-photon N00N state generation scheme using a single source of photons based on spontaneous parametric down-conversion (SPDC). The three-photon entangled state is generated when a photon is subtracted from a double pair of photons and detected by a heralding counter. Interference fringes measured with an emulated three-photon detector reveal the three-photon de Broglie wavelength and exhibit visibility > 70% without background subtraction.