Antiviral Effect of Amentoflavone Against Influenza Viruses.

Amentoflavone (AF) is a biflavonoid compound found in many plants. In this study, we first demonstrate that AF has a potent antiviral effect against the influenza virus via the inhibition of viral attachment and virucidal effects. The anti-influenza-viral effect of AF was evaluated using green fluorescent protein-tagged Influenza A virus (IAV) with fluorescent microscopy and flow cytometry analysis.

Ethanol Extract Attenuates Influenza A Virus Infection by Inhibiting Hemagglutinin and Neuraminidase.

is a perennial plant that is used for diverse diseases. This study investigated whether has an antiviral effect against influenza A virus (IAV) infection. We used green fluorescent protein (GFP)-tagged influenza A virus (IAV) to examine the effect of ethanol extract (STE) on influenza viral infection.

Lysophosphatidylcholines Promote Influenza Virus Reproduction through the MAPK/JNK Pathway in PMA-Differentiated THP-1 Macrophages.

Obesity and metabolic syndrome alter serum lipid profiles. They also increase vulnerability to viral infections and worsen the survival rate and symptoms after infection. How serum lipids affect influenza virus proliferation is unclear.

Design of a Novel Sericite-Phosphoric Acid Framework for Enhancement of Pb(II) Adsorption.

In this study, phosphoric acid was used to attach anions to the weak interlayer structure of sericite, one of the clay minerals composed of a tetrahedral structure of silicate, to increase the adsorption capacity of cations. Natural sericite beads (NSB) and activated sericite beads with phosphoric acid (PSB) were prepared as beads in order to increase reusability and facilitate the separation of adsorbates and adsorbents. Using this, lead (Pb(II)) removal efficiency from an aqueous solution was comparatively analyzed.

EGFR is a potential dual molecular target for cancer and Alzheimer's disease.

Many researchers are attempting to identify drugs that can be repurposed as effective therapies for Alzheimer's disease (AD). Several recent studies have highlighted epidermal growth factor receptor (EGFR) inhibitors approved for use as anti-cancer drugs as potential candidates for repurposing as AD therapeutics. In cancer, EGFR inhibitors target cell proliferation and angiogenesis, and studies in AD mouse models have shown that EGFR inhibitors can attenuate amyloid-beta (Aβ) pathology and improve cognitive function.

FeLaO fabricated biochar for removal of phosphorus in water and exploration of its adsorption mechanism.

Phosphorus (P) runoff from untreated wastewater and agricultural runoff has become an issue of concern because excessive P is detrimental to the health of water bodies and aquatic organisms such as fishes. Hence, different methods are being developed to salvage this challenge. However, most of the methods are expensive, while some are unsustainable.

Assessment of sludge reduction and biogas production in two-step anaerobic co-digestion using sesame oil cake and sewage sludge.

The aim of this study was to investigate the sewage sludge reduction and biogas production using two-stage anaerobic co-digestion of sesame oil cake and sewage sludge. In the first stage (acidogenic fermentation), sesame oil cake (SOC) was acidogenic fermented to produce fermented sesame oil cake (FSOC). In the second step (anaerobic co-digestion), sewage sludge and FSOC were mixed in various ratios of (100:0 (R1), 70:30 (R2), 50:50 (R3), and 30:70 (R4)) and observed for 30 days at a mesophilization temperature of 35±2 °C.

Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice.

The cholinesterase inhibitor donepezil is used to improve Aβ pathology and cognitive function in patients with Alzheimer's disease (AD). However, the impact of donepezil on tau pathology is unclear. Thus, we examined the effects of donepezil on Aβ and tau pathology in 5xFAD mice (a model of AD) in this study.

Optimization of the extraction conditions of Nypa fruticans Wurmb. using response surface methodology and artificial neural network.

In this study, we conducted response surface methodology (RSM) and artificial neural network (ANN) to predict and estimate the optimized extraction condition of Nypa fruticans Wurmb. (NF). The effect of ethanol concentration (X; 0-100%), extraction time (X; 6-24 h), and extraction temperature (X; 40-60 °C) on the antioxidant potential was confirmed.

Seed Exhibits Inhibitory Effect on Skin Senescence via SIRT1 and MMP-1 Regulation.

The seed is a by-product of the food industry, and we studied its potential as a food biomaterial, particularly for nutraceutical and inner beauty products. Alternative animal tests showed that an extract of ripened seed (PmRS) was not toxic on the skin. PmRS exhibited protective effects against ultraviolet- (UV-) induced skin aging in mice, confirmed by phenotypic indications, including increased collagen levels and decreased skin thickness.

High Resolution Mass Spectroscopy-Based Secondary Metabolite Profiling of (Burm. f) Stem Attenuates Oxidative Stress via Regulation of MAPK/Nrf2/HO-1/ROS Pathway.

The secondary metabolites profiling of stem (NNSE) extract was carried out using a high-resolution mass spectroscopic technique. The antioxidant effects of NNSE, as well as the underlying mechanisms, were also investigated in tert-butyl hydroperoxide (-BHP)-stimulated oxidative stress in RAW264.7 cells.

Protects HaCaT Cells from Oxidative Stress-Induced Cell Death through Nrf2-Mediated Heme Oxygenase-1 Expression via the Activation of p38 and ERK1/2.

Ultraviolet B (UV-B) radiation induces the extreme production of either reactive oxygen species (ROS) or inflammatory mediators. The aim of this study was to evaluate the antioxidant activities of 70% ethanolic extract of (LPE) and the underlying mechanisms using HaCaT cells exposed to UV-B. High-performance liquid chromatography (HPLC) confirmed the presence of gallic acid, catechin, and epicatechin in LPE.

Phytochemical Characterization of L. Bark by Paper Spray Ionization-Mass Spectrometry and Evaluation of Its Antioxidant Potential Against t-BHP-Induced Oxidative Stress in RAW 264.7 Cells.

The antioxidant effects of the ethyl acetate fraction of bark (DIBEt) and the underlying mechanisms were investigated in -butyl hydroperoxide (t-BHP)-stimulated oxidative stress in RAW 264.7 cells. Paper spray ionization-mass spectroscopy with positive-ion mode tentatively revealed 27 secondary metabolites in bark extract; predominant among them were alkaloids, phenolic acids, and flavonoids.

Protection against UVB-Induced Photoaging by via Inhibition of MAPK/AP-1/MMP-1 Signaling.

Ultraviolet B (UVB) irradiation is major causative factor in skin aging. The aim of the present study was to investigate the protective effect of a 50% ethanol extract from (NF50E) against UVB-induced skin aging. The results indicated that NF50E exerted potent antioxidant activity (IC = 17.

Acid-fermented fish by-products broth: An influence to sludge reduction and biogas production in an anaerobic co-digestion.

This study investigates the effects of anaerobic co-digestion of a fishery by-products broth (FFB) mixed with sewage sludge on biogas production and sludge reduction. A 5:5 mixing ratio of sewage sludge and FFB generated the highest removal efficiency of volatile solids (VS) (51.3%), total solids (TS) (48.

Assessment of the adsorption kinetics, equilibrium and thermodynamic for Pb(II) removal using a hybrid adsorbent, eggshell and sericite, in aqueous solution.

Hybrid adsorbents (ES) were prepared with mixing of eggshell and sericite as binders, and Pb(II) was removed from aqueous solutions. Sericite has the advantage of not only serving as a binder for hybrid adsorbent but also having a negative charge on the surface to improve the removal efficiency of heavy metals. Various parameters affecting the removal of Pb(II) from aqueous solutions were investigated using the optimal conditions derived.

Ventricular Septal Defect Closure in a Neonate with Osteogenesis Imperfecta.

A male patient weighing 2.5 kg was admitted for respiratory difficulty, and a large ventricular septal defect (VSD) was diagnosed. During care, sudden right leg swelling with a femur shaft fracture occurred.

Assessment of the adsorption kinetics, equilibrium, and thermodynamic for Pb(II) removal using a low-cost hybrid biowaste adsorbent, eggshell/coffee ground/sericite.

A hybrid adsorbent (CES), coffee grounds, eggshell powder and sericite as a binder, was prepared to remove Pb(II) from aqueous solution. The Fourier-transform infrared spectroscopy analysis showed that the CES contained a large amount of OH groups and had a favorable structure for adsorbing heavy metals. The value of pH of CES was estimated at 7.

Application of hybrid bead, persimmon leaf and chitosan for the treatment of aqueous solution contaminated with toxic heavy metal ions.

In this study, hybrid beads, which are made by mixing persimmon leaf and chitosan, was used to remove Pb(II) and Cd(II) from aqueous solution. According to the Fourier transform infrared spectrometry (FT-IR) analysis, the hybrid bead has a structure that enables the easy adsorption of heavy metals because it has carboxylic, carbonyl groups, O-H carboxylic acid, and bonded -OH groups. The adsorption of Pb(II) and Cd(II) by hybrid beads was more suitable with the Langmuir isothermal adsorption and showed an ion exchange reaction which occurred in the uneven adsorption surface layer.

Use of hybrid microcapsules, chitosan-methyl esterified sericite-tannin, for the removal of harmful lake algae and nutrient.

This paper outlines the development of a novel, low-cost, hybrid material from chitosan-methyl esterified sericite-tannin. The adsorbent material is then successfully utilized for the efficient removal of lake nutrients and harmful algae. In a FT-IR analysis, peaks related to -OH stretching, carbonyl and carboxylic groups, and CH stretching were newly created or expanded, and microcapsules were found to facilitate the removal of harmful algae and nutrients.

Cytotoxic properties of the anthraquinone derivatives isolated from the roots of Rubia philippinensis.

Background: Cancer is one of the most frequently occurring diseases and is the second leading cause of death worldwide. In this study, anthraquinone derivatives (Compounds 1-5) were evaluated for their anti-cancer potential against various skin and breast cancer cell lines to assess whether these anthraquinone derivatives may serve as a lead for the augmentation of anti-cancer drug.

Methods: Anthraquinone derivatives, 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-(6'-O-acetyl)-α-rhamnosyl(1 → 2)-β-glucoside (Comp 1), 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone (Comp 2), and alizarin (Comp 3) were isolated from the dichloromethane fraction of the roots of Rubia philippinensis.

Effectiveness of group cognitive behavioral therapy with mindfulness in end-stage renal disease hemodialysis patients.

Background: Many patients with end-stage renal disease (ESRD) undergoing hemodialysis (HD) experience depression. Depression influences patient quality of life (QOL), dialysis compliance, and medical comorbidity. We developed and applied a group cognitive behavioral therapy (CBT) program including mindfulness meditation for ESRD patients undergoing HD, and measured changes in QOL, mood, anxiety, perceived stress, and biochemical markers.

Antimelanogenic Effect of an Oroxylum indicum Seed Extract by Suppression of MITF Expression through Activation of MAPK Signaling Protein.

In this study, the antimelanogenic effect of an ethyl acetate fraction of Vent. seeds (OISEA) and its underlying mechanisms in melan-a cells were investigated. Antimelanogenesis activity was confirmed by assessing inhibition of tyrosinase activity and melanin content in the cells.

Airway Improvement with Medium-Term Compression Duration after Right Pulmonary Artery Anterior Translocation.

Left main bronchus compression occasionally occurs in patients with cardiac disease. A 19-month-old female patient weighing 6.7 kg was admitted for recurrent pneumonia and desaturation.