Publications by authors named "Hee-Il Lee"

Scrub typhus is caused by intracellular bacteria belonging to the genus . Until 2010, the endemic region was thought to be restricted to the Asia-Pacific region. species have recently been discovered in South America, Africa, Europe, and North America.

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Article Synopsis
  • Japanese encephalitis (JE) vaccination has been effective, but the emergence of a new genotype V (GV) of the virus in China and rising cases in South Korea are concerning challenges.
  • Analysis of serum samples from vaccinated individuals revealed that while they had strong neutralizing responses against the original genotype III (GIII) virus, their response against the new GV variants was significantly lower.
  • The findings indicate that existing GIII-based vaccines may not offer adequate protection against GV JEV, posing risks for populations in endemic areas and travelers.
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We developed a new concentration kit, called the ParaEgg (PE), for easy detection trematode eggs from fecal samples in endemic areas of clonorchiasis and metagonimiasis in Korea. To create a standard of detection efficiency, 120 fecal samples were examined using the water-ether concentration method (WECM). The PE kit and Mini ParaSep (PS) kit were used to compare the detection sensitivity of 100 egg-positive and 20 egg-negative samples in WECM.

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is one of the most medically important carriers of various pathogens. Although is an important vector, only basic ecological and biological information has been obtained, primarily focusing on its abundance and distribution. This study determined the most active time and meteorological conditions for the diel activity of .

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  • The study focuses on the prevalence of spotted fever group rickettsiae (SFGR), which cause tick-borne rickettsiosis, in ticks from the Republic of Korea (ROK).
  • Researchers aimed to accurately identify SFGR in ticks using molecular methods, including polymerase chain reaction and sequencing, to better understand infection rates.
  • Out of 302 collected ticks, the overall SFGR infection rate was found to be 26.8%, with peaks in June, highlighting the need for ongoing tick surveillance for public health management.
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Monitoring mosquito populations is essential for controlling mosquito-borne diseases, and the selection of mosquito traps should be tailored to specific surveillance objectives. Here, we tested four mosquito traps for their efficiency and applicability: the Nozawa-style black light trap (BLT), BG-sentinel trap II (BGT), UV-LED Blackhole Plus Mosquito Buster trap (LED), and digital mosquito monitoring system (DMS). The traps were rotated weekly for a 24 h cycle at the same location for 13 weeks.

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This study investigated the prevalence of and in 494 engorged ticks collected from various animal hosts, including cattle, horses, sheep, chickens, dogs, and cats, in six regions of northern Kyrgyzstan. Ten tick species, belonging to two families and six genera, were identified based on , 16S rRNA, and genes: (26.5%), (18.

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Japanese encephalitis (JE), caused by the Japanese encephalitis virus (JEV) infection, continues to pose significant public health challenges worldwide despite efficient vaccines. The virus is classified into five genotypes, among which genotype V (GV) was not detected for a long period after its initial isolation in 1952, until reports emerged from China and the Republic of Korea (ROK) since 2009. The characteristics of the virus are crucial in estimating its potential epidemiological impact.

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  • - The study examined the presence of parasitic protozoa in small mammals in the Republic of Korea (ROK), focusing on rodents and shrews as potential carriers of zoonotic diseases.
  • - A total of 331 blood samples were tested, finding 23.9% positive for one type of parasite and 10% for another; no samples tested positive for the third type.
  • - Key findings included the highest infection rates in Seogwipo-si and Gangneung-si, with the identification of different genotypes, including a newly found Kobe type, marking the first nationwide survey of these infections in ROK small mammals.
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sp. is the most common intestinal protozoan affecting human health worldwide. Several studies have reported the prevalence of sp.

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Mosquitoes, the primary vectors of arboviruses, harbor a diverse microbiome that plays a crucial role in their development, immunity, and vector competence. The composition of the mosquito microbiome is heavily influenced by the environment and habitats. Therefore, identifying the relationship between the habitat and the mosquito's microbial community can improve the overall understanding of mosquito biology.

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Ticks are important vectors of the tick-borne encephalitis virus (TBEV). In Kyrgyzstan, the livestock farming trade and nomadic lifestyle enable tick-borne diseases to be imported from neighboring countries, but there are few relevant studies. In this study, we collected 40 ticks from cattle in Kyrgyzstan.

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Tick-borne pathogens (TBPs), transmitted by the bites of ticks, are of great medical and veterinary importance. They include bacteria, viruses, and protozoan parasites. To provide fundamental data on the risk of tick contact and public health strategies, we aimed to perform a molecular investigation on four tick-borne bacterial pathogens in ticks collected from humans across the Republic of Korea (ROK) in 2021.

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Microbiota in the mosquito plays an important role in their behavior and vector competence. The composition of their microbiome is strongly influenced by the environment, especially their habitat. The microbiome profiles of adult female Anopheles sinensis mosquitoes from malaria hyperendemic and hypoendemic areas in Republic of Korea were compared using 16S rRNA Illumina sequencing.

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is a myxosporean parasite that infects the trunk muscles of olive flounder () and has been reported to cause foodborne illnesses in humans. However, the molecular mechanisms underlying spore toxicity remain largely unknown. In this study, the gastroenteropathy of was examined in human colon adenocarcinoma cells as well as experimental mice inoculated with spores.

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This study aimed to evaluate the positive rates for Enterobius vermicularis eggs among preschool children in Yeosu-si, Jeollanam-do, the Republic of Korea (Korea) over a period of 5 years (2017-2021). Perianal swab samples, obtained using cellotape, from 10,392 preschool children in 26 districts were examined microscopically for E. vermicularis eggs.

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Human babesiosis is a tick-borne disease induced by the genus Babesia and has been significantly reported in the Republic of Korea. This report shows the cases of 2 patients with human babesiosis who traveled to the USA in 2019. The 2 patients experienced fever and had travel histories to babesiosis-endemic regions.

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Leishmaniasis is a neglected tropical disease and an infectious disease transmitted by sandflies that occurs worldwide. In the absence of physicians seeking to identify the causes of disease in non-endemic areas, appropriate diagnoses cannot be made, thereby hampering effective treatment. In this report, we examined a nodular lesion on a patient's chin by performing a biopsy and molecular analysis.

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Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne infectious disease caused by Dabie bandavirus, commonly called SFTS virus (SFTSV). In the Republic of Korea (ROK), 1,504 cases of SFTS have been reported since the first human case was identified in 2013 until 2021. However, no case exists to provide molecular evidence between questing tick and patients with confirmed SFTS in the same living environment.

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Inflammatory bowel disease (IBD) is a chronic and recurrent illness of the gastrointestinal tract. Treatment of IBD traditionally involves the use of aminosalicylic acid and steroids, while these drugs has been associated with untoward effects and refractoriness. The absence of effective treatment regimen against IBD has led to the exploration of new targets.

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The positive rate of Clonorchis sinensis is the highest among intestinal parasites in the Republic of Korea (Korea). More than 1.2 million people were at risk of C.

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Human granulocytic anaplasmosis (HGA) and human monocytic ehrlichiosis (HME) are zoonotic tick-borne diseases transmitted via tick bites. To determine the state of human and infections caused by tick bites in the Republic of Korea (ROK), we conducted a nationwide investigation of human cases of tick bites in 2020. A total of 180 ticks were obtained, comprising (70.

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Article Synopsis
  • * Fecal samples from 1241 patients with acute diarrhea were analyzed in 2020, leading to the detection of 24 cases of one pathogen and one case of another using PCR techniques.
  • * The findings indicate that these pathogens are not only found in animals but also in humans in the ROK, highlighting the need for ongoing monitoring to track these agents in patients with acute diarrhea.
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The endemicity of zoonotic trematode metacercariae (ZTM) was investigated with total 871 freshwater fishes (19 species) from Deokcheon-gang (a branch stream of Gyeongho-gang) in Sancheong-gun, Gyeongsangnam-do, Korea for 3 years (2018-2020). All fishes were examined with the artificial digestion method. The metacercariae of Clonorchis sinensis (CsMc) were detected in 233 (36.

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The Korea Disease Control and Prevention Agency has established centers at 16 locations to screen vector populations and pathogens. The aims of this study were to determine the relative spatiotemporal distributions of mosquitoes that are flavivirus vectors, and to correlate them with instances of flaviviral disease in the Republic of Korea (ROK). We collected 67,203 mosquitoes in traps at 36 collection sites in 30 urban regions and migratory bird habitats in 2020.

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