Publications by authors named "Hee Tae Yoon"
Article Synopsis
- Inflammatory bowel disease may lead to a heightened risk of colitis-associated cancer (CAC), which this study investigates using mouse models.
- TLR3 was examined for its role in CAC, showing that TLR3 knockout mice had more severe colitis and a higher tumor burden compared to wild-type mice.
- The study concluded that enhancing TLR3 signaling could potentially serve as a therapeutic strategy to mitigate the development of CAC in patients with inflammatory bowel disease.
Article Synopsis
- - Psoriasis is a chronic inflammatory condition linked to the activation of the IL-23/IL-17 pathway and may be influenced by the gut-skin connection and intestinal microbiota.
- - Researchers studied the impact of clusterin, a glycoprotein, on psoriatic skin inflammation and related systemic issues in a mouse model, revealing that its absence reduced inflammation and altered gut microbiota composition.
- - High clusterin levels were found in the skin of psoriasis patients, suggesting that inhibiting clusterin could potentially reduce symptoms like skin inflammation and colitis while affecting gut microbiota ratios.
Article Synopsis
- Chronic intestinal fibrosis caused by recurring colitis is difficult to treat, especially with complications like stenosis and obstruction, and the role of Toll-like receptor 4 (TLR4) in this context is not well understood.
- In a study using both mouse models and human cells, researchers found that TLR4-deficient mice showed less inflammation and fibrosis, indicating TLR4 may promote processes leading to these conditions.
- The research suggests that targeting TLR4 signaling could offer new therapeutic strategies for managing intestinal fibrosis by reducing inflammation and collagen production.
