Publications by authors named "Hee Su Shin"
Article Synopsis
- Researchers have explored various cytokine approaches to trigger antitumor responses, but issues with effectiveness and side effects have limited their use.
- In this study, interleukin-7 was modified to exist as both a secretory form and a membrane-bound form fused with B7.1 on colon cancer cells, showing they could stimulate CD8 T cell activation and antitumor responses similarly in lab conditions.
- Notably, the membrane-bound IL-7/B7 form led to significantly lower tumor growth in mice and induced long-lasting immunity against tumor cells, indicating it may be a more effective strategy for improving cancer treatment.
Stresses and various infectious reagents caused multiple inflammatory diseases in swine in a livestock industrial environment. Therefore, there is a need for an effective therapeutic or preventive agent that could alleviate chronic and acute inflammation. We found that lysophosphatidic acid (LPA), a stress-induced potent endogenous inflammatory molecule, causes a broad range-regulation of inflammation related genes inflammation in swine macrophages.
View Article and Find Full Text PDFThe industrial livestock environment can cause stress and weakened immunity in cattle, leading to microbial infections which reduce productivity. As such, there is a need for an effective therapeutic agent that can alleviate uncontrolled destructive respiratory inflammation. We found that lysophosphatidic acid (LPA), a potent endogenous stress-induced inflammatory agent, causes respiratory tissue damage and triggers inflammation in bovine bronchial cells.
View Article and Find Full Text PDFBackground: Various techniques are used for performing breast reduction. Wise-pattern and vertical scar techniques are the most commonly employed approaches. However, a vertical scar in the mid-lower breast is prominent and aesthetically less pleasant.
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