Publications by authors named "Hee Kyung Seong"

Article Synopsis
  • AMIGO2 is a protein that facilitates liver metastasis in tumor cells, and altering its expression impacts the cells’ ability to metastasize.
  • The study aimed to find ways to reduce liver metastasis by lowering AMIGO2 levels, testing 285 compounds and identifying five that effectively inhibit tumor cell adhesion to the liver.
  • Among these, the clinically available drug ruxolitinib was found to significantly reduce AMIGO2 expression and could effectively prevent liver metastasis in both mouse and human cancer cells.
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Article Synopsis
  • Researchers identified AMIGO2 as a key driver gene in liver metastasis and poor outcomes for colorectal cancer (CRC) patients.
  • The study explored how AMIGO2 promotes epithelial-mesenchymal transition (EMT), which enhances the invasion potential of CRC cells, primarily through the activation of the TGFβ/Smad signaling pathway.
  • Findings indicate that AMIGO2 is significantly expressed in the invasive front of tumors and its nuclear presence is linked to EMT marker expression, suggesting it could be targeted for therapies aiming to inhibit metastasis in CRC.
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Background: Amphoterin-induced gene and open reading frame 2 (AMIGO2) have been reported to be related to the prognosis of colorectal, gastric, and cervical cancer. However, their association with ovarian cancer remains unclear. This study aimed to elucidate the role of AMIGO2 in ovarian cancer.

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The adhesion of circulating cancer cells to vascular endothelial cells is an initial and critical step in distant metastases. Amphoterin-induced gene and open reading frame 2 (AMIGO2) was found to regulate tumor cell adhesion to hepatic endothelial cells and act as a driver gene for liver metastasis in mouse cell lines. However, whether the role of AMIGO2 observed in mouse tumor cells can be extrapolated to human cancer cells in vivo has not been verified.

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There have been reports in Korea of imported malaria cases of four Plasmodium species, but there has been no report of imported Plasmodium ovale malaria confirmed by molecular biological methods. We report an imported case of that was confirmed by Wright-Giemsa-stained peripheral blood smear and nested polymerase chain reaction targeting the small subunit ribosomal RNA gene. The amplified DNA was sequenced and compared with other registered P.

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