Publications by authors named "Hee Kyeong Yoon"
Article Synopsis
- Despite advancements in medicine, sepsis continues to have a high mortality rate due to a lack of effective biomarkers for diagnosis and treatment guidance.
- High levels of WARS1, a protein associated with inflammation, are linked to early death in critically ill sepsis patients, indicating its role in disease severity.
- An experimental antibody that neutralizes WARS1 has shown promise in reducing inflammation and improving survival rates in severely septic mice, suggesting a new potential treatment strategy for sepsis.
Tryptophanyl-tRNA synthetase 1 (WARS1) is an endogenous ligand of mammalian Toll-like receptors (TLR) 2 and TLR4. Microarray data, using mRNA from WARS1-treated human peripheral blood mononuclear cells (PBMCs), had indicated WARS1 to mainly activate innate inflammatory responses. However, exact molecular mechanism remains to be understood.
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