Publications by authors named "Hee C Kim"
Background: Despite advancements in laparoscopic right hemicolectomy for right-sided colon cancer, the choice between functional end-to-end anastomosis and end-to-side anastomosis remains a topic of debate. This study aimed to compare these 2 techniques in terms of postoperative complications and disease-free survival.
Methods: This retrospective analysis included 1,202 patients who underwent laparoscopic right hemicolectomy for nonmetastatic colon cancer at Samsung Medical Center between January 2007 and February 2016.
Texture analysis generates image parameters from F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT). Although some parameters correlate with tumor biology and clinical attributes, their types and implications can be complex. To overcome this limitation, pseudotime analysis was applied to texture parameters to estimate changes in individual sample characteristics, and the prognostic significance of the estimated pseudotime of primary tumors was evaluated.
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- Neoadjuvant chemoradiotherapy may reduce the presence of exfoliated cancer cells in patients undergoing rectal washout surgery.
- A study involving 105 patients showed that those treated with chemoradiotherapy had a 0.0% rate of malignant cells in washout fluids, compared to 32.1% in those who did not receive the treatment.
- The findings suggest that rectal washout may not be needed for patients who have undergone neoadjuvant chemoradiotherapy, as it appears to effectively minimize the risk of local recurrence from exfoliated cancer cells.
Article Synopsis
- This study evaluates the effectiveness of colonoscopy in detecting recurrence of stage I colorectal cancer and identifies important recurrence risk factors.
- A retrospective analysis of over 2,200 patients showed high 5-year disease-free survival rates, but a small percentage experienced recurrence, with distinct patterns for colon and rectal cancer.
- The findings suggest that relying only on colonoscopy may miss significant recurrence cases, especially for high-risk patients who may benefit from additional CT scans for better detection and outcomes.
Article Synopsis
- This study examines OpenCap, a smartphone-based motion capture system, to analyze gait in patients with neurological disorders versus healthy controls.
- Results show patients had slower gait speeds, shorter stride lengths, and greater step length asymmetry, indicating substantial differences in movement patterns.
- OpenCap demonstrates effectiveness in identifying gait discrepancies and could improve accessibility to biomechanical assessments for better monitoring and treatment of neurological disorders.
Article Synopsis
- * Methods: It analyzed data from 682 patients treated with neoadjuvant chemoradiotherapy and total mesorectal excision at Samsung Medical Center, using various imaging methods to assess clinical staging and outcomes.
- * Results: Findings indicated that local recurrence occurred in 6.9% of patients, with positive circumferential resection margins, venous invasion, and perineural invasion as key risk factors; patients with complete resections had better survival rates, reinforcing the need for careful monitoring of high-risk individuals.
An interpretable tinnitus prediction framework using gap-prepulse inhibition in auditory late response and electroencephalogram.
Comput Methods Programs Biomed
October 2024
Article Synopsis
- Tinnitus is characterized by ringing in the ears without external sound, and current diagnostic methods rely heavily on subjective assessments and complex medical exams.* -
- The study collected EEG and auditory late response data from 44 tinnitus patients and 47 control subjects, developing a machine learning model that reached 90% accuracy in diagnosing tinnitus using specific auditory features.* -
- Findings suggest that measuring gaps in auditory response and EEG activity could provide reliable screening tools for tinnitus, supporting clinical practices in hearing research.*
Purpose: For the treatment of locally advanced rectal cancer (LARC), research on primary lesions with mesorectal fascia (MRF) involvement is lacking. This study analyzed the clinical outcomes and efficacy of dose-escalated neoadjuvant concurrent chemoradiotherapy (NCRT) to patients with LARC involving MRF.
Materials And Methods: We retrospectively reviewed 301 patients who were diagnosed with LARC involving MRF and underwent NCRT followed by total mesorectal excision (TME).
Article Synopsis
- - Electromyography (EMG) is being explored as a way to predict the severity of knee osteoarthritis (OA) by analyzing muscle activation patterns during walking, linked to patient-reported measures like WOMAC and VAS.
- - This study collected EMG data from the lower leg muscles of 84 patients with advanced knee OA to analyze how muscle activity and co-contraction relate to functional limitations experienced by these patients.
- - Using machine-learning models, the researchers found high accuracy (coefficient of determination) in predicting WOMAC and VAS scores based on muscle activity, revealing that greater muscle co-contraction correlates with more severe OA symptoms.
Background: This study aimed to analyze the correlation between the cycle threshold (Ct) values of severe fever with thrombocytopenia syndrome (SFTS) virus small (S) and middle (M) segments and the SFTS viral load, aiming to estimate the initial viral load and predict prognosis in the early clinical course.
Method: A retrospective study was conducted with confirmed SFTS patients at Jeju National University Hospital (2016-2022). Patients were categorized into non-fatal and fatal groups.
Article Synopsis
- - The study re-evaluates the assumption that colorectal carcinoma in situ (early-stage cancer) has no risk of spreading to nearby lymph nodes, noting isolated cases of metastasis and recurrence.
- - A retrospective analysis of 1,069 patients showed a low recurrence rate of 0.46%, but some cases revealed lymph node metastasis and distant spread of cancer after surgery.
- - The findings highlight the importance of thorough assessments during diagnosis, as colorectal carcinoma in situ can indeed recur and metastasize, necessitating careful monitoring of patients.
Article Synopsis
- The study focused on identifying prognostic factors for survival in 474 patients with locally advanced rectal cancer who showed strong treatment responses after neoadjuvant chemoradiotherapy.
- The analysis revealed that the circumferential resection margin and the use of adjuvant chemotherapy positively influenced disease-free survival, while the clinical N stage also played a role in overall survival.
- The study recommends close monitoring and consideration of adjuvant chemotherapy for patients with specific risk factors, such as a positive circumferential resection margin and clinical N (+) stage.
Objectives: This study aimed to evaluate the performance of artificial intelligence (AI) models using connected speech and vowel sounds in detecting benign laryngeal diseases.
Study Design: Retrospective.
Methods: Voice samples from 772 patients, including 502 with normal voices and 270 with vocal cord polyps, cysts, or nodules, were analyzed.
Article Synopsis
- This study compared long-term cancer outcomes between robotic and laparoscopic surgeries in patients with advanced rectal cancer after they received neoadjuvant chemoradiotherapy (nCRT).
- It analyzed data from 3240 rectal cancer patients, focusing on 1204 who received nCRT, and used propensity score matching to ensure fair comparisons between the two surgical methods.
- The results showed that the robotic surgery group had better 5-year disease-free and local recurrence-free survival rates, especially in patients with yp stage III cancer and other unfavorable factors, suggesting that robotic surgery may yield better oncologic outcomes.
Photoplethysmogram (PPG) performs an important role in alarming atrial fibrillation (AF). While the importance of PPG is emphasized, there is insufficient amount of openly available atrial fibrillation PPG data. We propose a U-net-based generative adversarial network (GAN) which synthesize PPG from paired electrocardiogram (ECG).
View Article and Find Full Text PDFBackground: The lungs are one of the most common sites for colon cancer metastasis. A few studies reported that approximately 2% to 10% of patients with colon cancer developed pulmonary metastasis. However, among these studies, patient characteristics were heterogeneous, and information on pulmonary metastasis incidence by the TNM stage was scarce.
View Article and Find Full Text PDFPrcis: Primary open angle glaucoma and pseudoexfoliation glaucoma showed different progression patterns of the retinal nerve fiber layer and ganglion cell-inner plexiform layer thinning in OCT-guided progression analysis.
Purpose: To compare the patterns of progression of retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thinning by guided progression analysis (GPA) of optical coherence tomography (OCT) in primary open angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG).
Materials And Methods: The progression of RNFL and GCIPL thinning was assessed by the GPA of Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA).
Article Synopsis
- The study aimed to evaluate how well deep-learning models can predict conversion to normal-tension glaucoma (NTG) in patients suspected of normotensive glaucoma.
- Researchers analyzed data from 12,458 eyes, using two types of fundus images and 15 clinical features to train machine-learning models (XGBoost, Random Forest, Gradient Boosting) for prediction.
- All models demonstrated high accuracy, with XGBoost performing best, identifying key clinical factors like baseline intraocular pressure and diastolic blood pressure as significant for determining the time to NTG conversion.
Purpose: With the advancement of deep neural networks in biosignals processing, the performance of automatic sleep staging algorithms has improved significantly. However, sleep staging using only non-electroencephalogram features has not been as successful, especially following the current American Association of Sleep Medicine (AASM) standards. This study presents a fine-tuning based approach to widely generalizable automatic sleep staging using heart rate and movement features trained and validated on large databases of polysomnography.
View Article and Find Full Text PDFBackground: Although bevacizumab is an important treatment for metastatic colorectal cancer (CRC), not all patients with CRC benefit from it; in unselected patient populations, only modest survival benefits have been reported.
Methods: We evaluated clinical outcomes in 110 patients using comprehensive molecular characterization to identify biomarkers for a response to bevacizumab-containing treatment. The molecular analysis comprised whole-exome sequencing, ribonucleic acid sequencing, and a methylation array on patient tissues.
Alterations in DNA methylation play an important pathophysiological role in the development and progression of colorectal cancer. We comprehensively profiled DNA methylation alterations in 165 Korean patients with colorectal cancer (CRC), and conducted an in-depth investigation of cancer-specific methylation patterns. Our analysis of the tumor samples revealed a significant presence of hypomethylated probes, primarily within the gene body regions; few hypermethylated sites were observed, which were mostly enriched in promoter-like and CpG island regions.
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- Predicting cancer recurrence in colorectal cancer (CRC) is crucial for enhancing patient outcomes, as different patients at the same tumor stage can have varying clinical results.
- The study presents a new method called NIMO, which integrates multiomics data to identify transcriptome signatures for better predicting CRC recurrence by analyzing immune cell methylation patterns.
- The effectiveness of this prediction approach was validated using data from two separate patient groups, showing that combining immune cell composition with traditional TNM staging significantly improves the accuracy of CRC recurrence predictions.
Background: The association of a micropapillary pattern with oncologic outcomes has not been fully studied in patients with colon cancer.
Objective: We evaluated the prognostic value of a micropapillary pattern, especially for patients with stage II colon cancer.
Design: A retrospective comparative cohort study using propensity score matching.